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senescence of human diploid fibroblasts,is upregulated by a transforming growth factorbetamediated signaling pathway[J].Biochem Biophys Res Commun,2004,318(4):819825.[5] BenitezRajal J,Lorite MJ,Burt AD,et a,291(5):G97786.[6] Sedlaczek N,Hasilik A,Neuhaus P,et overexpression of insulinlike growth factor 2 by hepatocytes and cholangiocytes in viral liver cirrhosis[J].Br J Cancer,2003, 88(5):733739. [7] Koutroubakis IE,Malliaraki N,Dimoulios PD,et al.Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease[J].Dig Dis Sci,2004,49(9):14331437. [8] Lin Y,Xie WF,Chen YX,et of experimental hepatic fibrosis by binational delivery of urokinasetype plasminogen activator and hepatocyte growth factor genes[J].Liver Int,2005,25(4):796807. [9] 馮海娟,[J].國際消化病雜志,2009 29(1): 4560。 [10] Oz HS,Chen TS,McClain CJ,et as novel therapy in a murine model of colitis[J]. J Nutr Biochem,2005,16(5):297304. [11] Iimuro Y,Nishio T,Morimoto T,et al. Delivery of matrix metalloproteinase1 attenuates established liver fibrosis in the rat[J].Gastroenterology,2003,124(2):445458.[12] Chou WY,Lu CN,Lee TH,et a.Electroporative interleukin10 gene transfer ameliorates carbon tetrachlorideinduced murine liver fibrosis by MMP and TIMP modulation[J].Acta Pharmacol Sin, 2006,27(4):469476. 內(nèi)容總結(jié) (1)肝硬化中肝星狀細(xì)胞信號分子的研究 2010級普外專業(yè)班李孝平(2010108)王軍宏(2010101)張斌(2010098)張臣民(2010106) 摘要:肝硬化是一種常見的慢性肝病,是多原因引起的肝臟損害,肝星狀細(xì)胞(HSC)在肝硬化、肝纖維化病程中起關(guān)鍵作用 (2)目前認(rèn)為,HSC有可能是通過分泌IL10等細(xì)胞因子,反饋調(diào)節(jié)庫普弗細(xì)胞的功能,從而參與調(diào)節(jié)肝臟炎性反應(yīng)及肝纖維化進(jìn)