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(10 PVCs/hr or 3 beats NSVT. ? Randomized ICD vs. no ICD. ? Standard heart failure medications. ? Primary endpoint mortality. Image (Heart Failure/Transplant) DEFINITE Trial 39 KB File Type: GIF Click here to nlarge / dow nload for presentation use (ie. Pow erPoint) Source Clinical Trials image provided by the American College of Cardiology Foundation DEFINITE Overall Conclusions ? Asymptomatic patients with ventricular arrhythmias and no underlying heart disease do not need to be treated. ? Symptomatic patients with arrhythmias should be treated with standard therapy and ICD. Management depends on the frequency and severity of the patient’s arrhythmia. Conclusions ? The results of AVID support using the ICD as firstline therapy to prolong total and/or sudden death survival in patients with documented unstable VT or VF. Conclusions ? MUSTT is concordant with MADIT, suggesting that risk stratification using invasive techniques should be the standard of care for postinfarction patients who have NSVT and significant LV dysfunction. Conclusions ? The patient with NICM and NSVT is difficult to risk stratify. If syncope has occurred, there is some data to support implantation of an ICD. ? In the asymptomatic patient, the answer is not clear at this time