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ias: Secondary Prevention ? Conclusions ? The results of AVID support using the ICD as frontline therapy to prolong total and sudden death survival in patients at high risk for sudden death LV function. ? This trial included patients with both ischemic and nonischemic substrates. ICD Therapy Primary Prevention ICM MADIT ? Multicenter Automatic Defibrillator Implantation Trial ? Hypothesis: ICD will reduce mortality (allcause) in highrisk CAD patients. Moss AJ. N Engl J Med. 1996。335:19331940. MUSTT Multicenter UnSustained Tachycardia Trial Sponsors: ? NHLBI and Industry Buxton AE. N Engl J Med. 1999。341:188290. MUSTT Protocol Randomized Treatment Groups Inducible Sustained VT N=704 No EPGuided Rx ACE I amp。B N=351 Buxton AE. N Engl J Med. 1999。341:188290. Nonischemic Cardiomyopathy and NSVT ? DEFIbrillators in Non ICM Treatment Evaluation (DEFINITE). – Multicenter randomized trial. – Non Ischemic Cardiomyopathy – LVEF 35%. – Symptomatic heart failure. DEFINITE ? Spontaneous arrhythmia (10 PVCs/hr or 3 beats NSVT. ? Randomized ICD vs. no ICD. ? Standard heart failure medications. ? Primary endpoint mortality. Image (Heart Failure/Transplant) DEFINITE Trial 39 KB File Type: GIF Click here to nlarge / dow nload for presentation use (ie. Pow erPoint) Sou