【文章內(nèi)容簡介】 3 mg/kg per 24 h IV/IM in 1 dose 2 weeks for native valve 6 weeks for prosthetic OR Vanycin 30 mg/kg per 24 h in 2 equal doses 4 weeks for native valve to maximum of 2 g/24 h 6 weeks for prosthetic 22 抗微生物治療 ? 營養(yǎng)變異性鏈球菌（ NVS）及青霉素高度耐藥者：萬古 6周 +慶大 6周 ? 肺炎鏈球菌：青霉素 4周或頭孢曲松 4周 ? 耐青霉素者：頭孢噻肟 4周或萬古 4周或頭孢曲松 +萬古 4周 23 腸球菌治療方案（一） ? Regimen Dosage and route Duration ? ? Susceptible to penicillin,gentamicin,and vanycin ? Ampicillin sodium 12g/24 h IV in 6 doses 4~6 weeks ? OR ? Penicillin G 1830million U/24h either continuously or 6 doses 4~6 weeks ? PLUS ? Gentamicin 3 mg/kg per 24h IV/IM in 3 equal doses 4~6 weeks ? OR ? Vanycin 30 mg/kg per 24h IV in 2 equally divided doses 6 weeks ? PLUS ? Gentamicin 3mg/kg per 24h IV/IM in 3 equal doses 6 weeks ? Susceptible to penicillin, streptomycin, vanycin, but resistant to gentamicin ? Amipicillin sodium 12 g/24h IV in 6 doses 4~6 weeks ? OR ? Penicillin G 1830 million U/24h either continuously or 6 doses 4~6 weeks ? PLUS ? Streptomycin sulfate 15mg/kg per 24h IV/IM in 2 equal doses 4~6 weeks ? OR ? Vanycin 30mg/kg per 24h IV in 2 equally divided doses 6 weeks ? PLUS ? Streptomycin sulfate 15mg/kg per 24h IV/IM in 2 equal doses 6 weeks 24 腸球菌治療方案（二） ? Regimen Dosage and route Duration ? Susceptible to aminoglycosides and vanycin but resistant to penicillin ? Betalactamase producing strain ? Ampicillinsulbactam(舒巴坦 ) 12g/24h IV in 4 doses 6 weeks ? PLUS ? Gentamicin 3mg/kg per 24h IV/IM in 3 equal doses 6 weeks ? OR ? Vanycin 30mg/kg per 24h IV in 2 equally divided doses 6 weeks ? PLUS ? Gentamicin 3mg/kg per 24h IV/IM in 3 equal doses 6 weeks ? Intrinsic penicillin resistance ? Vanycin 30mg/kg per 24h IV in 2 equally divided doses 6 weeks ? PLUS ? Gentamicin 3mg/kg per 24h IV/IM in 3 equal doses 6 weeks ? ? Resistant to penicillin, aminoglycosides, and vanvomycin ? (屎腸球菌） ? Linezolid(利鈉唑胺 ) 1200mg/24h IV/po in 2 equal doses ≥8weeks ? (糞腸球菌） ? Ceftriaxone sodium 2g/24h IV/IM in 1 doses ≥8weeks ? PLUS ? Ampicillin sodium 12g/24h IV in 6 doses ≥8weeks 25 葡萄球菌 IE抗菌素應用 TABLE 12. Oerview of therapy for endocarditis caused by staphylococcus Regimen Dosage and route Duration Methicillinsusceptible anisms(native valves) Nafcillin(新青 Ⅲ ) or oxacillin 12g/24h IV in 46 doses 6 weeks With option of gentamicin Gentamicin 3mg/kg per 24h IV/IM in 2 or 3 dose