【文章內(nèi)容簡介】 mega6 Saturated Food Perishable Durable Increased in System Short shelf life Processed foods factory farmed Increased in Long shelf life animals pasture fed animals Immune Antiinflammatory Inflammatory amp。 Inflammatory Properties Antiinflammatory Evolutionary Recent marked Recent marked Recent marked Context decline increase increase ↓Omega3, (↑Omega6) Insulin signaling ? ↑ blood sugar ? ↑ artery disease ? ↑ triglycerides Inflammation Oxidative stress Novel Nutrients Disrupt Insulin Signaling, Drive Inflammatory Metabolism Saturated fat ↓Antioxidants High Glycemic Carbohydrates Fructose ? Increase risks saturated and trans fats high glycemic carbohydrates lack of fruits/vegetables/omega 3s excess omega 6s? ? Reduce risks fruits, vegetables omega 3s low glycemic carbohydrates Mediterranean diet Influence of Nutrition on Chronic Disease Benefits of MediterraneanType Diet on Chronic Disease Risk Clinical intervention studies ? 70% ↓ heart attacks, cardiac death amp。 total mortality DeLogeril 94 ? 60% ↓ cardiac events in CVD patients* Ornish 98 ? ~50% ↓ metabolic syndrome Esposito 04 ? 39% ↓ in CRP Esposito 04 ? ↓insulin resistance Esposito 04 ? ↓ weight Esposito 04 Prospective observation studies ? 80% ↓ diabetes MartinezGonzalez 08 ? ~31% ↓ allcause amp。 cardiovascular mortality, 22% ↓ cancer mortality**calculated from Sofi 08 73% Alzheimer?s mortality Scarmeas 07 ? 2530% ↓ Parkinson?s disease Gao 07 ? 78% ↓ childhood asthma maternal diet Chatzi 08 *10% low fat, vegetarian diet + exercise, stress reduction **For every 2 point increase in adherence (on a 9 point scale), risk reductions were observed of for all cause mortality, for CV mortality, for occurrence and mortality from neoplasm. To convey the implications of these findings, we have applied the risk reductions across a 9 point adherence scale to yield a calculated ~31% ↓ allcause amp。 CV mortality and a 22% ↓ in cancer mortality. Benefits of SustainablyProduced Food Nutritional benefits: ?Generally higher levels of vitamins, minerals and phytochemicals (often dependent on soil quality) ?Higher Omega3 content ?Organic samples contained higher concentrations of polyphenols and antioxidants in 75% of the matched pairs representing those nutrients Benefits for farm workers and munities: ?Reduced exposure to pesticides Altered Pathways Environment Drives Chronic Disease Environmental Factors Chronic Disease Toxic Chemicals Air pollution, Lead and other heavy metals, some Pesticides, Bisphenol A and other Endocrine Disruptors Lead Cumulative occupational exposure ? ↑ cognitive impairment Shih 2022 ? 2x risk Parkinson?s Coon 2022 Cumulative munity exposure ? ↑cognitive impairment Shih 2022 ? Up to 15 years cognitive aging Weisskopf 2022 Animal studies of early life exposure ? Latelife Alzheimer?s markers Basha 2022, Lahiri 2022 Pesticides ? Parkinson’s Disease – Human studies 24/31 studies show ↑ risks for PD. (OR ) Brown 2022 – Animals Rotenone amp。 paraquat?damage dopaminergic neurons in striatal region of brain Uversky VN 2022 Combinations of maneb and paraquat。 prenatal exposure “primes” the brain, increasing adult susceptibility CorySlechta 2022 ? Cognitive decline/dementia – Low level fungicides in vineyards? poor atte