高原缺氧相關(guān)肺動脈高壓(編輯修改稿)
2024-11-16 05:34 本頁面
【文章內(nèi)容簡介】 肺動脈高壓及右心增大征象 – 經(jīng)臨床及心電圖等檢查排除心肌梗死、心力衰竭和肺炎等其他心肺疾患 – 經(jīng)臥床休息、吸氧等治療或下送 , 癥狀迅速好轉(zhuǎn) , X 線征象可于短期內(nèi)消失。 高原肺水腫影像學(xué)改變 高原肺水腫影像學(xué)改變 Radiograph of a 37yearold male mountaineer with HAPE that shows a patchy to confluent distribution of edema, predominantly on the right side CT scan of27yearold mountaineer with recurrent HAPE showing patchy distribution of edema 高原肺水腫影像學(xué)改變 高原肺水腫治療 ? 臥床休息 – 一旦發(fā)現(xiàn)病人 , 嚴禁繼續(xù)登高 , 絕對臥床休息 ? 下送原則 ? 氧療 – 是非常重要的治療方法 , 效果顯著 , 應(yīng)早期充分給氧 ? 一般采用持續(xù)低流量吸氧 ( 4 ~ 8L/ min) ? 對缺氧嚴重者可給予高流量持續(xù)吸氧 ( 10L/ min) ? 有條件時可應(yīng)用進行高壓氧治療 , 效果更好 ? 氧療加 NIPPV治療 ? 降低肺動脈壓的藥物 – 硝苯地平 – 氨茶堿 – 酚妥拉明 – 山莨菪堿 ? 利尿劑 ? 其他 – 激素 – Β2受體激動劑吸入 ? doubleblind study ? 14 healthy volunteers ? 100 mg sildenafil or placebo was administered ? exposure to hypobaric hypoxia at rest and after exercise to 5,000 m of simulated altitude ? Arterial oxygen saturation (SaO2), heart rate (HR), tidal volume (VT), respiratory rate (RR), left ventricular ejection fraction (EF), and pulmonary arterial pressure (PAP) were measured first at rest in normoxia, at rest and immediately after exercise during hypoxia, and after exercise in normoxia ? Th
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