黃酮類化合物和腦健康(參考版)
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【正文】 Nutr, 2022 Newly acquired Sensory information Shortterm memory Consolidation Longterm memory Memory Recall Slower Retrieval Rapid Retrieval Training/ Practice Memory Loss Acquisition Posttranslational modification of proteins De Novo protein synthesis Hippocampus Cortex Storage Spencer et al: Proceed Nutr Soc, 2022。 Nutr, 2022。 ABB, 2022 Vauzour et al: J Neurochem, 2022。 O126: 10 mM。 n=4) vehicle EC mM EC EC 1 EC 3 EC 10 Relative Band Intensity pERK2 pERK1 *** *** Flavonoids mediate CREB Activation pCREB (Ser133) total CREB basal 1 3 10 Epicatechin [mM] Epicatechin: 300 nM。 Schroeter et al: Biochem J, 2022 Flavonoid Activation of Prosurvival Signalling vehicle mM 44 42 pERK1/2 Total ERK ( 15 min。 Chem Soc Rev, 2022 Flavonoid Attenuation of Death Signalling *** 0 Band intensity *** Band intensity Band intensity Band intensity basal 54 H2O2 3’MEC 46 active JNK total JNK Flavonoid: mM OS: Peroxide: 50 mM H2O2 H2O2 EC basal H2O2 3’MEC H2O2 H2O2 EC Spencer et al: Biochem J, 2022。 Nutr, 2022。 Br J Nutr., 2022 Inhibition of Neuronal Injury by Flavonoids Control Ox. Stress (steadystate peroxide) EC + Ox. Stress MeEC + Ox. Stress % MTT reduction *** *** 0 20 40 60 80 100 120 Control Ox. Stress EC MeEC ECGluc Vehicle Spencer et al: Biochem J, 2022。 Brit. J. Nutr. 2022 3’Omethylepicatechin O C H 3O HOH OO HO HEpicatechin7sulphate O HO HOOO HO HSOOOEpicatechin7bD glucuronide O HO HOO HO HC O O HO HOOO HO HEpicatechin O HO HOH OO HO H Plasma concentration mM Major Flavonoid Metabolites Brain Uptake of Flavonoids 00 . 511 . 522 . 53T o ta lG SHV i ta m i nEV i ta m i nCmmol/g brain tissue00 . 0 40 . 0 80 . 1 20 . 1 60 . 2Pe l a r g o n i d i nnmol/g brain tissueAbd el Mohsen et al: FRBM, 2022。 Biochem J, 2022。 n=14). Subjects : 1830 yrs Subjects: 6075 yrs 36 40 44 48 52 56 60 Flavonoid Placebo * GoNoGo task: measures Executive function/attention Predrink 1h post 5h post Flavonoid Placebo * 36 40 44 48 52 56 60 Predrink 1h post 5h post Mean no. of correctly detected targets How are these effects mediated?
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