黃酮類化合物和腦健康-在線瀏覽
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【正文】 O HH OO HOONOLY294002 OOO HH 2 NPD98059 Epicatechin PI3 Kinase Inhibitor MEK Inhibitor OO HO HO HO HH OOQuercetin Similarity between flavonoids and kinase inhibitors Flavonoid interactions with neuronal and glial signalling IFN? IL1b TNFa CD23 p38 STAT1 iNOS NO ? TNFa Caspase8 Caspase9 Caspase3 Neuronal Apoptosis ROS/RNS Microglia/Astrocyte Neuron ASK1 JNK1/2 BAD BclxL DHBT1 ERK1/2 Akt MEK1/2 PI3K CREB Activation by Flavonoids Scavenging by Flavonoids Inhibition by Flavonoids Activation Inhibition CysDA Vafeiadou et al: EMID Drug Targets, 2022。 Genes amp。 ABB, 2022 Lee et al (2022) FRBM 40, 323334 FlavonoidInduced Signalling in Cancer Prevention Lee et al: FRBM, 2022 Nguyen et al: FRBM, 2022 Vauzour et al: ABB, 2022 Interaction of Flavonoids with the brains architecture of memory 26 The Sensory Input to the Hippocampus Rendeiro et al: Genes amp。 Chem Soc Rev, 2022 ERK1/2/5 CREB CaMK II/IV PKA PKB/Akt PKC Neurotrophins . BDNF eNOS NO Angiogenesis mTOR Arc/ Bactin Synaptic plasticity Memory and Learning Neurogenesis Synapse remodelling Translation Efficiency Control of Memory at the Molecular Level Spencer et al: Chem Soc Rev, 2022 Changes in Hippocampal CREB pCREB1 (Ser 133) CREB1 Y Y O B O B Hippocampus Cortex pCREB1 (Ser 133) CREB1 0 1 2 3 4 Hippocampus Cortex a *** Relative Band Intensity pCREB/ CREB Aged Young Aged + BB a = p ? *** = p ? Williams et al: FRBM, 2022 Proneurotrophin precursors also mediate biological functions ? Polymorphism that replaces valine for methionine at position 66 of the pro domain, is associated with memory defects and abnormal hippocampal function in humans Hippocampal changes in pro and mature BDNF Y Y O B O B ProBDNF BDNF GAPDH *** a Y O B Relative Band Intensity *** b ProBDNF Mature DDNF a/b = p ? *** = p ? Changes in Hippocampal ERK1/2 pERK 44 pERK 42 Y Y O B O B ERK2 pERK 44 pERK 42 a *** b ** Relative Band Intensity pERK/ERK Aged Young Aged + BB a/b = p ? *** = p ? ** = p ? ERK PKC CREB PKA CaMK Hippocampal changes in Akt pAkt (Ser 473) Akt PKA C CaMKIV (Thr 196) CaMKIV Y Y O B O B pAkt (Ser 473) CaMKIV (Thr 196) PKA (Thr 197) *** b Relative Band Intensity a a Aged Young Aged + B
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