一般臨床藥物代謝動力學回顧2(1)-資料下載頁
2025-02-05 17:44本頁面
【正文】 CL cr (ml/min, fem) = () (CLcr in males) Estimated Elimination Rate Constant for Aminoglycosides Gentamicin, Tobramycin ke = (CrCl) + .01 Amikacin ke = (CrCl) + .01 Vanycin ke = (CrCl) + .0044 Clinical Question? A 60 year old woman in the intensive care unit has Pseudomonas pneumonia and is started on ceftazidime and tobramycin. The physician asks you to remend an initial dosage regimen for tobramycin. Wt = 52kg Ht = 5’4” SCr = What initial regimen would you remend? Answer to Clinical Question IBW = kg +( x 4 in.) = Actual weight = 52 kg Dosing weight = 52 kg LD = Cp x Vd LD = 10 mcg/ml x L/kg x 52 kg = 156 mg (round to 160 mg) Answer to Clinical Question Desired Trough = mcg/ml Est. ke = (CrCl) + Est CrCl = 48 ml/min (x for female) = ml/mn (Please use 48 ml/min as the CrCl for this question since the author neglected to multiply by for female and the calculations continue on using 48 ml/min.) Est ke = (48) + = 14060 yrs x 52 kg = 72 kg Answer to Clinical Question Halflife = ke = = hours 10 mcg/ml 5 mcg/ml mcg/ml mcg/ml mcg/ml hours x 4 = 22 hours Answer to Clinical Question Ct = Co x e ke t = 10 x e t t = hours (round to 24 hours) Initial Regimen: 160mg IV q24 hr Sampling Considerations in Therapeutic Drug Monitoring Steady State Time from last dose administered Assessment of the appropriateness of specimen collection 謝謝觀看 /歡迎下載 BY FAITH I MEAN A VISION OF GOOD ONE CHERISHES AND THE ENTHUSIASM THAT PUSHES ONE TO SEEK ITS FULFILLMENT REGARDLESS OF OBSTACLES. BY FAITH I BY FAIT
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