【正文】
G Rosenfeld. The InsulinLike Growth FactorBindingProtein (IGFBP6) Superfamily[J]. Endocrine Reviews, 1999, 20(6):761787[2] Salmon W, Daughaday W. A hormonally controlled serum factor which stimulatessulfation incorporation by cartilage in vitro[J]. Lab Clin Med, 1957, 49:825836[3] Froesch E R, Muller W A, Burgi H et al. Nonsuppressibleinsulinlikeactivity of human serum. II. Biological properties of plasma extractswith nonsuppressible insulinlike activity[J]. Biochim Biophys Aeta, 1966. 121:360374[4] Dulak N C, Temin H M. A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication—simulating activity fro embryo fibroblasts[J]. Cell Physiol, 1973, 8l:153160[5] Daughaday W H, Hall K, Raben M S et al. Somatomedin: proposed designation for sulphation factor[J]. Nature, 1972, 235:107[6] Daughaday W, Rotwein P. Insulinlike growth factors I and II peptide messenger ribonucleic acid and gene structures, serum and tissue concentrations[J]. Endocr Rev, 1989, 10:6891[7] Rosenfeld R, Wilson D, Lee P et al. Insulinlike growth factors I and II in the evaluation of growth retardation[J]. Pediatr, 1986, 109:428[8] Rotwein P. Structure, evolution, expression and regulation of insulinlike growth factors I and II[J]. Growth Factors, 1991, 5:318. [9] Kornfeld S. Structure and function of the mannose 6phosphate/insulinlike Growth factor II receptors[J]. Annu Rev Biochem. 1992, 61:307330[10] Jones J I, Clemmorts D R. Insulinlike growth factors and their binding proteins: Biological Actions[J]. Endocr Rev, 1995, 16:3234[11] Jones J I, Clemmorts D R. Insulinlike growth factors and their binding proteins: Biological Actions[J]. Endocr Rev, 1995, 16 (2):334[12] Andress D L, Birnbaum R S. Human osteoblastderived insulinlike growth factor (IGF) binding protein5 stimulates osteoblast mitogenesis and polentiates IGF action[J]. Biol Chem, 1992. 267: 2246722472[13] Jones J I, Gockerman A, Busby Jr W H et al. Clemmons D growthfactor binding protein 1 stimulates cell migration and binds to the 5β1 integrinreceptor by means of its ArgGlyAsp sequence[J]. Proe Natl Acad Sci USA, 1993, 90:1055310557[14] Oh Y, Muller H L, Lamson G et al. Insulinlike growth factor(IGF)independent action of IGFbinding protein3 in Hs578T human breast cancerCells[J]. Biol Chem. 1993b, 268:1496414971[15] Jones J I. Clemmons D R Insulinlike growth factors and their binding proteins: Biological actions[J]. Endocr Rev, 1995, 16:334[16] Kelley K M, OH Y, Gargosky S E, Gacev Z, Matsumoto T, Hwa V, Ng L, Simpson D M, Rosenfeld R G. Insulinelike growth factorbinding protaln(IGFBPs)and theirRegulatory dynamics[J]. Int Biochen Cell Biol, 1996. 28(6):619637[17] Jones J I. Clemmorts D growth factors and their binding proteins: biological actions[J]. Endocr Rev, 1995, 16:334 [18] 顧以韌,張凱,李明洲,(IGFs)系統(tǒng)基因的發(fā)育表達(dá)模式[J].遺傳,2009,31(8):8384.致 謝本論文是在導(dǎo)師張紅平教授的悉心指導(dǎo)下完成的,從論文選題、試驗(yàn)設(shè)計(jì)、數(shù)據(jù)處理、寫(xiě)作上都凝聚著導(dǎo)師的大量心血。張老師和藹寬厚的胸懷、嚴(yán)謹(jǐn)?shù)闹螌W(xué)態(tài)度、開(kāi)闊的思維、敏銳的學(xué)術(shù)洞察力、執(zhí)著的學(xué)術(shù)信念和人格魅力,感染并鞭策我不斷前行、不斷探索。在此,謹(jǐn)向張紅平教授致以最衷心的感謝!感謝占思遠(yuǎn)師兄在試驗(yàn)和論文寫(xiě)作過(guò)程中的幫助!最后,感謝父母多年來(lái)給予我的關(guān)懷、支持和理解,感謝所有關(guān)心、支持和幫助過(guò)我的所有老師、同學(xué)和朋友!