碳水化合物代謝ppt課件-資料下載頁
2025-05-02 08:05本頁面
【正文】 H－ C－ OH | H－ C－ OH | CH2OH CH2OPO32 | C＝ O | CH2OH H－ C＝ O | H－ C－ OH | CH2OPO32－ Dihydroxyacetone phosphate triose phosphate isomerase Glyceraldehyde 3phosphate aldolase CHO | H－ C－ OH | CH2OH Glyceraldehyde triose kinase ATP ADP Fructokinase ATP ADP B. Galactose Is Converted to Glucose 1Phosphate ? The disaccharide lactose, present in milk, is a major source of energy for nursing mammals. ? In newborns, intestinal腸內(nèi)的 lactase catalyzes the hydrolysis of lactose to its ponents, glucose and galactose, both of which are absorbed from the intestine and transported in the bloodstream. OOHHHHHOOHH OHHCH 2OP 3O 2OOHHHHOO HH OHHCH 2 OHPOO HOHOOHHOHHO HH OHHCH 2 OHPOU M POHPhospho gluutase OOHHHOHHOHH OHHCH 2OHOOHHOHHO HH OHHCH 2OHPOO HOHOOHHHHOO HH OHHCH 2 OHPOU M POHGalactokinase ATP ADP Galactose Galactose1phosphate UDPglucose UDPgalactose Glucose1phosphate Glucose6phosphate Galactose1phosphate uridylyltransferase ? Conversion of galactose to glucose 6phosphate. ?The metabolic intermediate UDPglucose is recycled in the process. ?The overall stoichiometry for the pathway is galactose +ATP → glucose 6 phosphate + ADP UDPglucose 4epimerase Galactosemia半乳糖血 (癥 ) ?Infants fed an exclusive diet of milk rely on galactose metabolism for about 20% of their caloric intake. ?In the most mon form of the geic disorder galactosemia (the inability to properly metabolize galactose), infants are deficient in galactose 1phosphate uridylyltransferase. ? Deficiency of galactose1 phosphate uridylytransferase. ? galactose1phosphate accumulates ? Leads to liver damage ? Can be treated with galactose free diet. OOHHHHHOOHH OHHCH2OP3O2 OOHHHHOOHH OHHCH2OHP OOHOHOOHHOHHOHH OHHCH2OHP OUMPOHPhospho gluutase OOHHHOHHOHH OHHCH2OH OOHHOHHOHH OHHCH2OHP OOHOHOOHHHHOOHH OHHCH2OHP OUMPOHGalactokinase ATP ADP Galactose Galactose1phosphate UDPglucose UDPgalactose Glucose1phosphate Glucose6phosphate Galactose1phosphate uridylyltransferase C. Mannose Is Converted to Fructose 6Phosphate ? Mannose甘露糖 can be phosphorylated to mannose6phosphate by hexokinase and then converted to fructose6phosphate by phosphomannose isomerase. OOHOHHHHOO HH HHCH 2OHOOHOHHHHOO HH HHCH 2OPO32－ Phosphomanose isomerase Hexokinase ATP ADP 2－ O3P CH 2 OH O OH 2 C H O H HO H OH Glucose G6P F6P 1,6FBP G3P DHAP G3P 1,3BPG 3PG 2PG PEP Pyruvate 1,3BPG 3PG 2PG PEP Pyruvate Galactose1P UDPGal UDPGlucose Glucose1P Mannose Mannose6P Fructose–6P Dglyceraldehyde aldolase Triose kinase Galactose Fructose Thank you
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