蛋白質(zhì)高級(jí)結(jié)構(gòu)ppt課件-資料下載頁
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【正文】 化是球狀蛋白質(zhì)的普遍現(xiàn)象，不正常聚合成纖維狀可導(dǎo)致疾??； 四、穿膜區(qū)一定呈 α螺旋結(jié)構(gòu)，側(cè)鏈外露。 變性與復(fù)性 復(fù)旦大學(xué)生物化學(xué)系 黃偉達(dá) 蛋白質(zhì)的折疊過程很象左圖中的繩子自然落下的過程，不會(huì)出現(xiàn)右圖中的“打結(jié)”現(xiàn)象。 復(fù)旦大學(xué)生物化學(xué)系 黃偉達(dá) ? 蛋白質(zhì)與人工合成的高分子 聚合物 (高分子化學(xué)合成而 成 ) 的本質(zhì)性區(qū)別是什么 ? 思考題 思考題： 復(fù)旦大學(xué)生物化學(xué)系 黃偉達(dá) The first threedimensional structure of a biopolymer was the DNA model built by J. D. Watson and F. H. C. Crick in 1953 taking into account fiber diffraction data provided by M. H. F. Wilkins and others (Nobel Prize in Physiology or Medicine, 1962). Here is a copy of the original paper submitted to Nature on April 2, 1953 and published on April 25, 1953. The first threedimensional protein structures (myoglobin and hemoglobin) were determined by M. F. Perutz and J. C. Kendrew (Nobel Prize in Chemistry, 1962). The entries included in the PDB (PDB codes: 1mbn and 2dhb) represent refined structures. J. C. Kendrew had obtained a myoglobin structure at a resolution of 6 ? already in 1957. A. Klug has contributed substantially to the development of electron microscopy. This method is suitable for systems that cannot be crystallized (Nobel Prize in Chemistry, 1982). A. Klug has applied this method primarily to virus structures (see for example, Finch, Klug, J. Mol. Biol. 1965, 13, 112). The structure of the first membranebound protein (a photosynthetic reaction centre。 PDB code: 1prc) was resolved by J. Deisenhofer, R. Huber and H. Michel (Nobel Prize in Chemistry, 1988). The first threedimensional protein structure determined by NMR spectroscopy (proteinase IIa inhibitor from bull seminal plasma (PDB codes: 1bus, 2bus) was reported by K. W252。thrich and coworkers in 1985 (Nobel Prize in Chemistry, 2022). 研究生物大分子歷史上“第一”們
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