藥代動(dòng)力學(xué)總論-資料下載頁
2024-10-31 02:14本頁面
【正文】 intercept for the various types of data sets. 4. The student shall demonstrate (III) the proper procedures of mathematical and algebraic manipulations. 5. The student shall demonstrate (III) the proper calculus procedures of integration and differentiation. 6. The student shall demonstrate (III) the proper use of computers in graphical simulations and problem solving. 7. Given information regarding the drug and the pharmacokinetic assumptions for the model, the student will construct (III) models and develop (V) equations of the ADME processes using LaPlace Transforms. 8. The student will interpret (IV) a given model mathematically. 9. The student will predict (IV) changes in the final result based on changes in variables throughout the model. 10. The student will correlate (V) the graphs of the data with the equations and models so generated.,第六十五頁，共八十一頁。,A10n Where A is a value between 1 and 10, and n is a positive or negative integer AEn 2.28E4 =2.28 104 = 22800,第六十六頁，共八十一頁。,有效數(shù)字(yǒu xi224。o sh249。 z236。),第六十七頁，共八十一頁。,An where A is a number, which may be positive or negative, and n is the index, which may be positive or negative. Multiplication〔乘法(ch233。ngfǎ)〕 AnAm= An+m AnBm =〔A/B〕n Bn+m,第六十八頁，共八十一頁。,(b) Division 〔除法(chfǎ)〕 An/Am= Anm An/Bm =〔A/B〕n Bnm Raising to a Power〔冪〕 (An)m = Anm (i) Negative Index An=1/An (ii) Fractional Index A1/n = n√A (iii) Zero Index A0= 1,第六十九頁，共八十一頁。,LOGARITHMS〔對(duì)數(shù)(du236。 sh249。)〕 A =10n Log(A) = n NATURAL LOGARITHMS e = 2.7182818‥‥ ln(A)=2.303log(A) log(A)=0.4343ln(A),第七十頁，共八十一頁。,(a) Multiplication: To multiply NM , where N=en, and M=em。 NM =enem = en+m ln(NM) = n+m ln(NM) = ln(N) + ln(M),第七十一頁，共八十一頁。,(b) Division ln(N/M) = ln(N) ln(M) (c) Number Raised to a Power ln(Nm) = mln(N) (i) Number Raised to a Negative Power ln(Nm) = mln(N)= mln(1/N) (ii) Number Raised to a Fractional Power ln(m√N(yùn)) = ln(N1/m)= 1/mln(N) (iii) Logarithm of Unity ln(1) = log(1) = 0,第七十二頁，共八十一頁。,第七十三頁，共八十一頁。,第七十四頁，共八十一頁。,2.3 Calculus,2.3.2 NONLINEAR GRAPHS 2.3.3 SLOPE OF NONLINEAR GRAPH 2.3.4 VALUE OF THE SLOPE 2.3.5 DIFFERENTIATION FROM FIRST PRINCIPLES 2.4 Graphs 2.4.1 GRAPHICAL CONVENTIONS 2.4.2 STRAIGHT LINE GRAPHS,第七十五頁，共八十一頁。,第七十六頁，共八十一頁。,第七十七頁，共八十一頁。,第七十八頁，共八十一頁。,第七十九頁，共八十一頁。,第八十頁，共八十一頁。,內(nèi)容(n232。ir243。ng)總結(jié),Basic pharmacokinetics。生物利用度與生物等效性。種族差異、家族差異。屢次給藥旨在穩(wěn)態(tài)血藥濃度達(dá)有效濃度范圍: MTCCssMEC。CL=CL腎臟＋CL肝臟(gānz224。ng)＋CL其它。Css,max=F?D/?Vd(1e?τ) ?。AnAm= An+m。An/Am= Anm。An=1/An。100%,第八十一頁，共八十一頁。
職業(yè)教育相關(guān)推薦
鄂ICP備17016276號(hào)-1