臨床藥理學(xué)總論-資料下載頁(yè)
2025-01-05 15:22本頁(yè)面
【正文】 4 突變純合子和雜合子的個(gè)體發(fā)生嚴(yán)重不良反應(yīng)的風(fēng)險(xiǎn)增加 7倍 4級(jí)粒細(xì)胞減少癥發(fā)生率(%) 6/6 6/7 7/7 50% % 0% 100 50 0 10% ALL 基因型 頻 率： 10% 40% 50% 伊立替康 ADRs發(fā)生率與 UGT1A1*28頻率相關(guān) Potential of UGT Testing to Inform Dosing All Patients with Same Diagnosis (10% risk) PGx profile (7/7) for high risk (50%): treat with alternative drug or dose PGx Profile (7/6) for moderate risk (%): treat with alternative drug or dose PGx Profile (6/6) for low risk (0%): treat with conventional dose FDA修改伊立替康說(shuō)明書(shū) On July 7, 2023, the FDA approved revisions to the safety labeling for irinotecan HCl injection (Camptosar, made by Pfizer, Inc.) to remend reduced dosing in patients who are homozygous for the UDPglucuronosyltransferase 1A1 (UGT1A1)–*28 allele. 20 Century DisgnosisDirected Therapy One drug one dose for all patients Clinical Diagnosis Concentional Dose Safe/Effective Ineffect/Toxicity Dose Modification /Alternative Drug Safe/Effective 21 Century GenotypeDirected Therapy Right drug dose for right patient Clinical Diagnosisi Durg Choice/Dosage Safe/Effective Genotype Detection New Era of Personalized Therapy ? Personalized Medicine: tailoring individual drug for each individual patient based on his or her geic make up ? 根據(jù)個(gè)體的遺傳結(jié)構(gòu)對(duì)每一個(gè)體實(shí)行量體裁衣的藥物治療 什么是個(gè)體化用藥？ Clinical Service for Personalized Medicine ? Hunan Consultant Center for Tailored Drug Therapy Mutant Alleles ? DME ? Transporters ? Receptors Large dose Modulation dose Reduce dose or Change drug Clinical Diagnosis Geic Test for Tailored Drug Center Centers of Clinical Service for PM in China Thank you ! 謝謝觀看 /歡迎下載 BY FAITH I MEAN A VISION OF GOOD ONE CHERISHES AND THE ENTHUSIASM THAT PUSHES ONE TO SEEK ITS FULFILLMENT REGARDLESS OF OBSTACLES. BY FAITH I BY FAITH
教學(xué)課件相關(guān)推薦
鄂ICP備17016276號(hào)-1