【正文】 力農(nóng)選擇性作用于肺血管。 ? 中國醫(yī)師進修雜志 2022 年 １０ 月 ２５ 日第 ３０ 卷第 １０ 期綜合版 負荷量注射后對血漿激素水平的影響 表明米力農(nóng)具有強心和擴血管作用。同時可降低血管緊張素 Ⅱ 、內(nèi)皮素、心鈉素水平。其機理可能是隨著心衰和血液動力學(xué)改善而改變。 The Effect of Milrinone on Platelet Activation as Determined by TEG174。 Platelet Mapping? 2022 International Anesthesia Research Society Vol. 108, No. 5, May 2022 CONCLUSIONS: Therapeutic blood concentrations of milrinone exhibit a significant inhibitory effect on ADP and AAinduced platelet activation as determined by TEG Platelet Mapping, without affecting the conventional kaolinactivated TEG. We suggest that TEG Platelet Mapping results be interpreted with caution in patients being treated with milrinone, and other drugs that modify platelet cyclic nucleotide concentrations. Milrinone for the Treatment of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage Stroke. 2022。39:893898 Methods—Twentytwo consecutive patients with angiographicallyproven CVS (arterial diameter reduction 40%). Intraarterial milrinone was infused in the cerebral territory(ies) involved and followed by continuous intravenous infusion until Day 14 after initial bleeding. We evaluated angiographic reversal of CVS, hemodynamic tolerance, and neurological oute 1 year after aSAH. Conclusion—This study suggests that milrinone is effective and safe for reversal of CVS after aSAH Constitutive Phosphodiesterase Activity Restricts Spontaneous Beating Rate of Cardiac Pacemaker Cells by Suppressing Local Ca2+ Releases ? Circ Res. 2022 Apr 11。102(7):7619. Figure 1. Suppression of PDE activity in SANCs dramatically increases cAMP and spontaneous beating rate. ?Figure 2. A parison of relative changes in the spontaneous SANC beating rate produced by specific inhibitors of different PDE subtypes. Figure 3. Effects of the specific PDE3 inhibitor milrinone or a broadspectrum PDE inhibitor, IBMX, on the firing rate of SANCs with normal and inhibited RyR function. Figure 4. PDE inhibition–induced potentiation of Ltype Ca2+ current amplitude is not affected by ryanodine. Figure 5. PDE3 inhibition increases the frequency and changes spatiotemporal properties of LCRs in intact SANCs. ? Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn Pediatr Crit Care Med. 2022 Jan。10(1):10612. Prostacyclin and iloprost are dilators of PAs from PPHN lambs and their effect is enhanced by milrinone. This bination therapy may be an effective strategy in the management of patients with PPHN. Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure J Transl Med. 2022 Jul 29。7:67 Do not to change indicative of accelerated myocardial injury. increased cardiac output and reduction in NTproBNP levels. there was no significant change in TnI or MYO after 24 hours of milrinone pared to baseline. there were significant reductions in inflammatory and apoptotic signaling with milrinone infusion. The Efficacy of Intravenous Milrinone in Left Ventricular Restoration Ann Thorac Cardiovasc Surg 2022。 15: 233–238 Conclusion: In those patients who underwent LVR because of ischemic cardiomyopathy, the administration of milrinone achieved safe perioperative management for stable hemodynamics and reduced the postoperative doses of dobutamine and epinephrine. 靜脈維持量對 CHF的心功能影響 氣道超聲霧化米力農(nóng)的影響 不同負荷劑量對 CHF的血流動力學(xué)的影響 謝謝大家