醫(yī)學(xué)ppt課件】信號(hào)傳導(dǎo)的病理生理學(xué)-資料下載頁(yè)
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【正文】 uthern MedicalUniversity Systems Biology: A New Paradigm H ORMetabolomics Genomics Proteomics Functional Proteomics/Genomics Transcriptomics Systems Biology Southern MedicalUniversity What is the “ OMICS” Revolution? Genomics Proteomics/ Functional Proteomics Metabolomics 1. Analysis of whole anism, cell or anelle 2. Driven by platform technologies 3. Characterized by rapid parallel throughput analyses 4. Generation of massive plex data blocks Southern MedicalUniversity Functional Scales of Systems Molecular Interactions (GO) Mechanisms Pathways / Networks Roles and Controls Process Hierarchy (GO) Purpose and Diseases Southern MedicalUniversity Understanding from Systems Biology DNA RNA Protein Cell Tissue Organ Individual Genomics Transcriptomics Proteomics Metabolomics Differential Proteomics Functional Proteomics Gene Sequences。 SNPs mRNA Levels Entire Protein Compliment Proteins Present/Absent in Affected versus Normal System Protein Modifications。 Protein/DNA, Protein/RNA, Protein/Ligand, Protein/Protein Interactions Protein Function。 Cell, Tissue, Organ, Individual Interactions Pharmacogenomics Southern MedicalUniversity Pharmacogenomics Discovery Target validation Lead Generation Lead Optimization Clinical Trials Drug Discovery Proteomics CombiChem Bioinformatics Functional Genomics HTS Rational Design Structural Proteomics Animal Models Systems Biology QSAR Southern MedicalUniversity ? Target identification ? Target validation ? Diagnostic and prognostic biomarkers ? Disease progression models ? Pharmacology and toxicology ? Inclusion/exclusion criteria for clinical trials ? Drug response profiles Systems Biology can be used for… Southern MedicalUniversity Platform for Systems Biology ppm 0 1 2 3 4 5 6 7 8 9 Complex Cellular Samples bodyfluids, tissue Dynamics . environmental + time Gene Protein Metabolite ? Objective is to link gene response, protein activity, metabolite dynamics to disease and interventions Quantitative Comparisons Targets Biomarkers BioSystematicsTM protein index metabolite index Southern MedicalUniversity THANKS FORYOURATTENTION Southern MedicalUniversity ACKNOWLEDGEMENT
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