醫(yī)學(xué)ppt課件】信號傳導(dǎo)的病理生理學(xué)(編輯修改稿)
2025-02-04 01:13 本頁面
【文章內(nèi)容簡介】 + + + PMA + + + SB203580 _ + + + PD98059 + + + Southern MedicalUniversity + + + + + HSP27 p38? + + + Fold of Activation 0 5 10 15 20 B A Electrophoresis pH + + p38?PRAK(182A) + p38?PRAK(182D) p38?PRAK(wt) T182 is the regulatory phosphorylation site of PRAK Southern MedicalUniversity 3. 提出 MAPK L12磷酸化環(huán)狀結(jié)構(gòu)影響底物特異性的觀點(diǎn) Southern MedicalUniversity MAPK Dural Phosphorylation Sites L12 Length * * hp38 DFGLARHTDDEMTGYVATRWYRAPE 25 hP38? DFGLARQADEEMTGYVATRWYRAPE 25 hp38? DFGLARQADSEMTGYVVTRWYRAPE 25 hp38? DFGLARHADAEMTGYVVTRWYRAPE 25 hJNK1 DFGLARTAGTSFMMTPYVVTRYYRAPE 27 hJNK2 DFGLARTACTNFMMTPYVVTRYYRAPE 27 hJNK3 DFGLARTAGTSFMMTPYVVTRYYRAPE 27 hERK1 DFGLARIADPEHDHTGFLTEYVATRWYRAPE 31 hERK2 DFGLARVADPDHDHTGFLTEYVATRWYRAPE 31 hBMK1 DFGMARGLCTSPAEHQYFMTEYVATRWYRAPE 32 YHOG1 DFGLARIQDPQMTGYVSTRWYRAPE 25 YSMK1 DFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPE 36 YMPK1 DFGLARGYSENPVENSQFLTEYVATRWYRAPE 32 YKSS1 DFGLARCLASSSDSRETLVGFMTEYVATRWYRAPE 35 YFUS3 DFGLARIIDESAADNSEPTGSGMTEYVATRWYRAPE 38 domain VII VIII Loop12(TLoop) sequence of MAP kinases Southern MedicalUniversity Construction of p38 loop12 to ERK like structure p38 ...DFGLARHTDDEMTGYVATRWYRAPE... p38(E) ...DFGLARHTDDEMTEYVATRWYRAPE... p38(6+) ...DFGLARHTDDEHDHTGFMTGYVATRWYRAPE... p38(6+E) ...DFGLARHTDDEHDHTGFMTEYVATRWYRAPE... p38(VAP) ...DFGLARVADPEMTGYVATRWYRAPE... p38(DL) ...DFGLARHTDDDLTGYVATRWYRAPE... p38(VAPD6+LE) ...DFGLARVADPDHDHTGFLTEYVATRWYRAPE... ERK2 ...DFGLARVADPDHDHTGFLTEYVATRWYRAPE... Southern MedicalUniversity MAPK MKK Substrates Loop12 is a key structure to determine the selection of substrate ? ? (...TXY...) Southern MedicalUniversity 4. p38 通過磷酸化 MEF2C，調(diào)節(jié) cJun的基因表達(dá) Southern MedicalUniversity Identification of MEF2C as a substrate for p38 Southern MedicalUniversity T293,T300 and S387 of MEF2C is p38 phosphorylation sites Southern MedicalUniversity Induction of cJun through MEF2C phosphorylation by p38 Southern MedicalUniversity MKK4 MKK3 MKK6
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