20xx年醫(yī)學(xué)專題—神經(jīng)系統(tǒng)藥理—吳希美(解熱鎮(zhèn)痛藥(編輯修改稿)
2024-11-12 18:05 本頁(yè)面
【文章內(nèi)容簡(jiǎn)介】 doses (0.3～0.6 g): antipyretic and analgesic effects larger doses (3～5 g/d): antiinflammatory and antirheumatic effects。 only relieves symptoms. to treat acute rheumatic fever(急性(j237。x236。ng)風(fēng)濕熱), to abate pain and symptoms of rheumatic amp。 rheumatoid arthritis (風(fēng)濕性和類風(fēng)濕性關(guān)節(jié)炎).,B. Salicylates,第十九頁(yè)，共四十頁(yè)。,(2) Inhibition of platelet aggregation small doses (30～100 mg/d): inhibiting TXA2 synthesis, preventing thrombosis. used to treat ischemic heart disease, reduce the mortality of myocardiac infarction, and prevent cerebral thrombosis. larger doses: inhibiting PGI2 synthesis, promoting thrombosis. PGI2: vasodilation and platelet depolymerization (血小板解聚).,B. Salicylates,第二十頁(yè)，共四十頁(yè)。,The mechanism of aspirin: Target enzymes acetylated,第二十一頁(yè)，共四十頁(yè)。,3. Adverse effects (1) GI reactions stimulating gastric mucosa and CTZ (larger doses)。 inhibiting PG synthesis in GI tract irritant symptoms。 gastric bleeding。 ulcerous disorders Contraindications: ulcerous disorders,B. Salicylates,第二十二頁(yè)，共四十頁(yè)。,(2) Prolongation of bleeding time small doses: inhibiting platelet aggregation larger doses: inhibiting synthesis of thrombogen Contraindications: one week prior to surgery。 severe hepatic damage。 vitamin K deficiency,。 prothrombinopenia (凝血酶原減少(jiǎnshǎo)癥).,B. Salicylates,第二十三頁(yè)，共四十頁(yè)。,(3) Allergic rea
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