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Adv Drug Rev, 2020, 59: 1521. 常州工程職業(yè)技術(shù)學(xué)院畢業(yè)設(shè)計(jì)(論文) 共 71 頁(yè) 第 15 頁(yè) 常州工程職業(yè)技術(shù)學(xué)院 畢業(yè)設(shè)計(jì)報(bào)告(論文) — 課題英文文獻(xiàn)翻譯 ( 2020 屆) 系 別: 制藥與生物工程技術(shù)系 課題名稱(chēng) : 胰島素新劑型的研究與進(jìn)展 指導(dǎo)教師: 潘玉琴 班 級(jí): 化學(xué)制藥技術(shù) 0821 學(xué)生姓名: 劉津民 常州工程職業(yè)技術(shù)學(xué)院畢業(yè)設(shè)計(jì)(論文) 共 71 頁(yè) 第 16 頁(yè) Research progress on insulin administration route for patients Lu Fengdi,Zhu Wei,Kan Kai (Affiliated Sixth People’s Hospital of Shanghai Jiao tong University, Shanghai 202033 China) Abstract For many years, insulin is administrated by subcutaneous injections to treat patients with diabetes. In order to enhance the medication pliance of diabetes patients, scholars of both abroad and at home go in for study on non injection way of administration and probe into an ideal administration route of insulin so as to enhance the therapeutic effect of insulin. Key words insulin。 dosage form。 administration route Insulin (insulin, INS) is a peptide drugs to treat diabetes, since 1921, Banting and Best discovered for the first time in the clinical application of INS has been using subcutaneous injection. For decades, people in order to improve the efficacy of INS, INS formulations continuous improvement, constantly updated INS injection devices, but these methods are ultimately inseparable from the injection means. Therefore, application of noninjecting means INS has been an ideal way for people to explore. INS agents, including noninjecting means of lung inhalation,oral preparations, mucosal delivery formulations and trandermal delivery systems [1]. Due to many new technologies, to the INS, the application of noninjecting means a very good development. INS is now the present we reviewed the route of administration. 1 INS injection injection Different parts of the INS be fast or slow absorption of subcutaneous abdominal injection absorbed the fastest, followed by upper arms, thighs, buttocks. INS also absorbed dose levels and physical activity, the greater the dose, the higher the concentration, slower absorption and absorption rate of movement will increase. Abdominal area, there are advantages of subcutaneous injection, usually the abdomen of adulttype arrangement for rotation or subcutaneous injection, as two distance 2 cm, can be injected with 180 points [2], 3 times per day calculated for continuous injection 2 months later to the cycle. infusion Mainly applied to diabetic ketoacidosis, hyperosmolar nonketotic diabetic a, severe trauma, infection, surgical treatment of perioperative who use intravenous 常州工程職業(yè)技術(shù)學(xué)院畢業(yè)設(shè)計(jì)(論文) 共 71 頁(yè) 第 17 頁(yè) infusion of small doses of available INS. INS pump INS pump treatment of diabetes, can effectively simulate the continuing based on INS secretion and meal pulsed release, the INS infusion into the patient39。s body to maintain blood levels of INS, shorten time to control high blood sugar and reduce the occurrence of low blood sugar, reduce Patients suffering multiple subcutaneous INS, INS pump is the best means of intensive therapy. intramuscular INS intramuscular absorption of fast, poor absorption by subcutaneous injection for, INS has a large amount of blood sugar can not control those who unconditionally infusion mild ketoacidosis INS patients. 2 INS administration of noninjecting means Local Administration For diabetic patients with diabetic foot ulcers or pressure sores [3] patients in the affected area when dealing with the INS bined with metronidazole, such as Fuyu anisodamine wounds, dressings opened the next day, showing significantly reduced secretion of shallow the site of rupture of small wounds, or 4 d 3 d scab healing。 deep muscle can gradually see the wound granulation, after 12 weeks of dressing, the wound healing scab. inhalation Relative to the absorption of peptide drugs, the lungs have more advantages, such as large alveolar surface area (50 m2 ~ 140 m2), very thin alveolar membrane, rich capillary work, and not the first highpermeability pass effect, narrow blood path, low activity, deep slow lung clearance rate, etc., these good physical environment for the absorption of peptide provided favorable conditions [4].In recent years, progressive pulmonary route of administration attention. INS inhalation require special technologies and facilities, mon technologies that are Techno sphere and AIR [5]. Most clinical trials show that in type 1 and type 2 diabetes patients, the inhaled and subcutaneous INS INS pared with the same safety and effectiveness, and more receptive to the patient [68]. INS agents present pelling pulmonary delivery, which people with diabetes will be a great blessing. Oral administration Route of administration of oral administration is the most convenient of all kind, patient pliance is best. H