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ith lowmolecularweight dextran for 48 hours (p ) and 120 hours (p ) pared with patients treated with aspirin (ASA). 51%29%7%0102030405060A S A 48 h ou r s 120 h ou r s% Complications(Disa JJ, Polvora VP, Pusic AL, Singh B, Cordeiro PG. Dextranrelated plications in head and neck microsurgery: do the benefits outweigh the risks? A prospective randomized analysis. Plast Reconstr Surg. 2022 Nov。112(6):15349.) Critical Appraisal Skills Programme (CASP) Screening Questions Y/N Comment 1. Did the study ask a clearly focused question? Consider if the question is ‘focused’ in terms of – the population studied – the intervention given – the outes considered Y Population right。 Intervention right。 Oute: benefit/risk 2. Was this a randomised controlled trial (RCT) and was it appropriately so? Consider: – why this study was carried out as an RCT – if this was the right research approach for the question being asked Y For such a therapy question, a systematic review is not available, a RCT is the right approach, and this is an RCT. Is it worth continuing? Free Flap Survival in Literature. Source No, of cases Flap survival (%) Anticoagulation age