黃酮類化合物和腦健康(編輯修改稿)
2025-06-22 22:12 本頁面
【文章內(nèi)容簡介】 HOOO HO HEpicatechin O HO HOH OO HO H Plasma concentration mM Major Flavonoid Metabolites Brain Uptake of Flavonoids 00 . 511 . 522 . 53T o ta lG SHV i ta m i nEV i ta m i nCmmol/g brain tissue00 . 0 40 . 0 80 . 1 20 . 1 60 . 2Pe l a r g o n i d i nnmol/g brain tissueAbd el Mohsen et al: FRBM, 2022。 Free Radic Res., 2022 。 Br J Nutr., 2022 Inhibition of Neuronal Injury by Flavonoids Control Ox. Stress (steadystate peroxide) EC + Ox. Stress MeEC + Ox. Stress % MTT reduction *** *** 0 20 40 60 80 100 120 Control Ox. Stress EC MeEC ECGluc Vehicle Spencer et al: Biochem J, 2022。 FRBM, 2022 Neurotransmitter Receptor PKC PI 3kinase Tyrosine kinase MAP kinase cascades JNK p38 ERK1/2 Akt/PKB Neuronal survival and Plasticity Neuronal Apoptosis CREB cjun Brain Ageing Increases in cognition performance and memory Williams et al: FRBM, 2022 Spencer et al: Genes amp。 Nutr, 2022。 Brit J Nutr, 2022。 Chem Soc Rev, 2022 Flavonoid Attenuation of Death Signalling *** 0 Band intensity *** Band intensity Band intensity Band intensity basal 54 H2O2 3’MEC 46 active JNK total JNK Flavonoid: mM OS: Peroxide: 50 mM H2O2 H2O2 EC basal H2O2 3’MEC H2O2 H2O2 EC Spencer et al: Biochem J, 2022。 FRBM, 2022。 Schroeter et al: Biochem J, 2022 Flavonoid Activation of Prosurvival Signalling vehicle mM 44 42 pERK1/2 Total ERK ( 15 min。 310 K。 n=4) vehicle EC mM EC EC 1 EC 3 EC 10 Relative Band Intensity pERK2 pERK1 *** *** Flavonoids mediate CREB Activation pCREB (Ser133) total CREB basal 1 3 10 Epicatechin [mM] Epicatechin: 300 nM。 15 min。 O126: 10 mM。 LY294002: 35 mM 0 basal EC 300 nM EC 300 nM UO126 EC 300 nM LY294002 EC 300 nM LY294003 UO126 Relative band intensity pCREB (Ser133) MEK inhibitor PI3K inhibitor OO HO HO HH OO HOONOLY294002 OOO HH 2 NPD98059 Epicatechin PI3 Kinase Inhibitor MEK Inhibitor OO HO HO HO HH OOQuercetin Similarity between flavonoids and kinase inhibitors Flavonoid interactions with neuronal and glial signalling IFN? IL1b TNFa CD23 p38 STAT1 iNOS NO ? TNFa Caspase8 Caspase9 Caspase3 Neuronal Apoptosis ROS/RNS Microglia/Astrocyte Ne
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