腎上腺素受體激動藥-在線瀏覽
2024-12-06 17:32本頁面
【正文】 ns of epinephrine or norepinephrine ? Sympathomimetic drugs Chemistry ? Parent pound: phenylethylamine ? Change the affinity for α or β receptors ? Change pharmacokiics properties 第一節(jié) 構(gòu)效關(guān)系及分類 Chemistry and pharmacokiics ? Substitutions – On the benzene ring: increase bioavailability and prolongs the duration of action。 increase the distribution of molecule to CNS – On the alpha or beta carbons: block oxidation by MAO – On the terminal amino group: increase β receptors activity – isomer Classification ? Depend on the affinity for different groups of receptor ? α, βadrenoceptor agonists ? αadrenoceptor agonists ? βadrenoceptor agonists α、 βR agonist ? Adrenaline ? Dopamine ? ephedrine Adrenaline ? At low concentration ,β effects predominate。 increase in heart rate , and increase cardiac output。blood vessel constrict。 coronary artery dilate。 cardiac output Pharmacological Effects ? Blood pressure: both systolic and diastolic pressure increase ? Others: blood sugar at high concentration pharmacokiics ? . drip. ? Be uptake and metabolized quickly ? excretion: VMA,normetanephrine Therapeutic Uses ? Neurogenic shock ? Hypotension ? Hemorrhage of upper digestive tract Adverse reaction ? Avascular necrosis ? Acute renal failure ? Contraindication: hypertension, atherosclerosis, cardiopathy Metaraminol ? excite
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