腎上腺素受體激動藥(存儲版)
【正文】 α、 βR agonist ? Adrenaline ? Dopamine ? ephedrine Adrenaline ? At low concentration ,β effects predominate。Block the release of histamine(β2 effects) – gastrointestinal tract – bladder – Eye: ocular pressure reduction – skeletal muscle Pharmacological Effects ? Metabolic effects – increase in glucoses and lactate production via glycogenolysis – inhibition of insulin secretion (αR) – increase in free fatty acid and oxygen consumption . Pharmacological Effects ? CNS – At therapeutic doses – In toxic doses, excitement, agitation, convulsion pharmacokiics ? Adr absorption is poor with oral administration ? Adr absorption is slow with hyodermic administration ? can be given iv or im Therapeutic Uses ? cardiac arrest ? anaphylactic shock ? Asthma and acute hypersensitivity reaction ? prolong the duration of local anesthesia ? Glaua Adverse Effects ? Palpitation, headache ? BP , arrhythmia ? Hypertension, diabetes mellitus, hyperthyroidism Drug interactions ? General anesthetics ? Psychotropic drugs ? βblockers Ephedrine ? absorbed when taken orally ? CNS effects may occur: such as insomnia, nervousness, nausea and agitation ? resistant to COMT and MAO, so that its action is prolonged ? Little effect on metabolism ? Acute tolerance pharmacological Effects ? Cardiac output , HR ? Blood vessel ? Blood pre
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