腎上腺素受體激動藥-文庫吧在線文庫
【正文】 ssure ? Relax smooth muscle ? skeletal muscle ? CNS: excitement ? Tachyphylaxis Clinical Uses ? Bronchial asthma ? Nasal decongestant ? Hypotension without crisis ? Adverse reactions: CNS Dopamine ? activate α、 β1 and dopareceptor ? Be metabolized by MAO and COMT quickly ? No effect on CNS Dopamine ? Blood vessels – At low or intermediate concentration: act on D1 receptor, dilate – At high concentration : act on αreceptor, constrict ? Heart: positive inotropic effect on the myocardium, increase cardiac output Pharmacological Effects ? Kidney – At low or intermediate concentration: reduce arterial resistance in the mesentery and kidney – At high concentration: cause vasoconstriction with consequent reduction in renal function Clinical uses ? Shock ? Acute renal failure ? Adverse reaction: arrhythmia, reduction in renal function ? Drug interactions αadrenoceptor agonists ? Norepinephrine(NA/NE) ? Metaraminol ? α 1 adrenoceptor agonists: phenylephrine and methoxamine ? α 1 adrenoceptor agonists: oxymetazoline,apraclonidine NA/NE ? Potent effect of α receptor ? Relative little effect on β1 receptor ? Little effect on β2 receptor Pharmacological Effects ? Blood vessels: constrict (skin vessels, renal vessels)。 dizziness ? overdosage by inhalation can produce fatal ventricular arrhythmia ? Contraindication: my
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