腎上腺素受體激動藥(完整版)
【正文】 ocarditis ,coronary heart disease。 – coronary artery dilate – a propensity toward arrhythmias Pharmacological Effects ? blood pressure – At low concentration: systolic pressure increase – At high concentration: both systolic and diastolic pressure increase Pharmacological Effects ? Smooth muscle: – Bronchus:Bronchiolar smooth muscle relaxes(β2 effects)。 increase in heart rate , and increase cardiac output。 pharmacological Effects ? blood pressure: diastolic blood pressure falls , systolic blood pressure increase ? Relax both bronchial and gastrointestinal smooth muscle ? Metabolic effects pharmacokiics ? Resistance to MAO ? less be uptaken ? aerosol Clinical uses ? Bronchial asthma ? Atrioventricular block ? Cardiac arrest ? Shock Adverse Effects ? palpitation。 coronary artery dilate。第十章 腎上腺素受體激動藥 Adrenoceptor Agonists definition ? Drugs that mimic the actions of epinephrine or norepinephrine ? Sympathomimetic drugs Chemistry ? Parent pound: phenylethylamine ? Change the affinity for α or β receptors ? Change pharmacokiics properties 第一節(jié) 構(gòu)效關(guān)系及分類 Chemistry and pharmacokiics ? Substitutions – On the benzene ring: increase bioavailability and prolongs the duration of action。 negative feedback (α2 effects) ? Heart: pacemaker activity, conduction velocity, and intrinsic contractility increase. HR decre
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