腎上腺素受體激動藥-展示頁
2024-10-28 17:32本頁面
【正文】 ion: cause vasoconstriction with consequent reduction in renal function Clinical uses ? Shock ? Acute renal failure ? Adverse reaction: arrhythmia, reduction in renal function ? Drug interactions αadrenoceptor agonists ? Norepinephrine(NA/NE) ? Metaraminol ? α 1 adrenoceptor agonists: phenylephrine and methoxamine ? α 1 adrenoceptor agonists: oxymetazoline,apraclonidine NA/NE ? Potent effect of α receptor ? Relative little effect on β1 receptor ? Little effect on β2 receptor Pharmacological Effects ? Blood vessels: constrict (skin vessels, renal vessels)。 – coronary artery dilate – a propensity toward arrhythmias Pharmacological Effects ? blood pressure – At low concentration: systolic pressure increase – At high concentration: both systolic and diastolic pressure increase Pharmacological Effects ? Smooth muscle: – Bronchus:Bronchiolar smooth muscle relaxes(β2 effects)。 at high concentration , α effects predominate. ? β2R are more sensitive to Adr than the αR. Pharmacological Effects ? Blood vessel – α effects: constrict (skin vessels, renal vessels) – β2 effects: dilate( vessels in skeletal muscle vessels) – Coronary blood flow – pulmonary blood flow – Blood redistribution Pharmacological Effects ? Heart – direct effect on β1R 。第十章 腎上腺素受體激動藥 Adrenoceptor Agonists definition ? Drugs that mimic the actio
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