【正文】
術(shù), 其作用尚不明確 ?靶向藥物新輔助治療可使腫瘤縮小 ?腫瘤原發(fā)灶 ?腫瘤原發(fā)灶伴腔靜脈癌栓 ?局部復(fù)發(fā)病灶 ?轉(zhuǎn)移病灶 . . . 但需要個體化治療 ?靶向藥物新輔助治療尚需前瞻性研究以明確其作用 靶向治療評估 sunitnib治療后分子標(biāo)志物 ? 77% of the response could be predicted: if VEGF difference was observed, 80% of patients had clinical response. But if VEGF surexpression was absent 70% of the patients had no clinical response. ? This study suggested that surexpression of VEGF in the front of metastatic renal cell carcinoma pared to the center could be a predictive factor of response to sunitinib. Sorafenib與 sunitinib的序貫治療 ?回顧性分析 118例多中心先后采用 Sorafenib與sunitinib的腎癌患者 . ?研究結(jié)果表明 sorafenib 和 sunitinib之間不存在交叉抗藥性 . 總體疾病無進(jìn)展生存時間在 sorafenibsunitinib 組比 sunitinibsorafenib 更長 . Bastien L., et al. Eur Urol 2023。72:864–868 治療時間 (天 ) 32 72 217 47 235 262 23 43 38 107 47 縮小率 (%) 腎癌伴多發(fā)淋