脂肪酸的代謝ppt課件(參考版)
2025-01-07 20:50本頁面
【正文】 。 （重點(diǎn)） 。 脂蛋白顆粒的胞吞和降解 LDL受體的結(jié)構(gòu) SREBP activation. Sterol regulatory elementbinding proteins (SREBPs, shown in green) are embedded in the ER when first synthesized, in a plex with the protein SREBP cleavageactivating protein (SCAP, red). (N and C represent the amino and carboxyl termini of the proteins.) When bound to SCAP, SREBPs are inactive. When sterol levels decline, the plex migrates to the Golgi plex, and SREBP is cleaved by two different proteases in succession. The liberated aminoterminal domain of SREBP migrates to the nucleus, where it activates transcription of sterolregulated genes. Regulation of cholesterol formation balances synthesis with dietary uptake. Glucagon promotes phosphorylation (inactivation) of HMGCoA reductase。 and LDL, 20 to 25 nm. 脂類是由脂蛋白運(yùn)輸?shù)? Lipoproteins and lipid transport. (a) Lipids are transported in the bloodstream as lipoproteins, which exist as several variants that have different functions, different protein and lipid positions, and thus different densities. Dietary lipids are packaged into chylomicrons。 VLDL, 28 to 70 nm。能源物質(zhì)過剩時(shí)，膽固醇的合成速度加快，午夜時(shí)，合成速度較快，膳食固醇類，特別是植物固醇可抑制膽固醇的合成。 前列腺素內(nèi)過氧化物合成酶催化PGH2的合成 阿斯匹林使環(huán)加氧酶失活 甲羥戊酸的合成 甲羥戊酸合成的機(jī)制 HMGCoA還原酶的活力受合成速度、降解速度及磷酸化和脫磷酸調(diào)控。 血小板活化因子 :1烷基 2乙酰甘油磷酸膽堿的合成 物合成由 3酮鞘氨醇合成酶催化的反應(yīng)開始 3酮鞘氨醇 二氫鞘氨醇 N脂酰二氫鞘氨醇 神經(jīng)酰胺 動(dòng)物細(xì)胞中糖基神經(jīng)酰胺，神經(jīng)節(jié)苷脂和鞘磷脂的由神經(jīng)酰胺合成。 adoMet is Sadenosylmethionine。 this increases the flux through the triacylglycerol cycle. The glycerol freed by the breakdown of triacylglycerol in adipose tissue is released to the blood and transported to the liver, where it is primarily converted to glucose, although some is converted to glycerol 3phosphate by glycerol kinase. Thiazolidinediones activate a nuclear receptor called peroxisome proliferatoractivated receptor γ (PPARγ), which induces the activity
教學(xué)課件相關(guān)推薦
鄂ICP備17016276號-1