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logy will enhance understanding of the causes of HF Currently used ACEI, betablockers and CRT have clear benefits to clinical outcomes of HF Development in bioengineering could have an enormous beneficial impact on both incidence and management,Chronic heart failure (CHF),Definition a complex clinical syndrome with typical clinical symptoms that can occur at rest or on effort, and is characterised by objective evidence of an underlying structural abnormality or cardiac dysfunction that impairs the ventricle to fill with or eject blood The term congestive heart failure is no longer used.,MADITII,Moss AJ. N Engl J Med. 2002。346:87783.,,,,Defibrillator,Conventional,P = 0.007,1.0,0.9,0.8,0.7,0.6,0.0,Probability of Survival,0,1,2,3,4,Year,No. At Risk Defibrillator 742 502 (0.91) 274 (0.94) 110 (0.78) 9 Conventional 490 329 (0.90) 170 (0.78) 65 (0.69) 3,Nonpharmacological Physical activity tailored to individuals Walk Slow walking at home 1030 min a day, 7 days a week Class IV patients require gentle mobilisation as symptoms allow Bed rest for those with acute deterioration of symptoms,Nonpharmacological Sodium restriction 3 g sodium/day No more than 2 L fluid intake per day Daily weighing Weight variation should be 2 kg in two consecutive days,Katz, A. M. Circ Heart Fail 2008。1:6371,Two views of the circulation,Starling curve,Katz, A. M. Circ Heart Fail 2008。1:6371,Proliferative signaling pathways that mediate cardiac hypertroph