20xx年醫(yī)學專題—第一講-心臟泵血功能10-資料下載頁
2024-11-16 00:30本頁面
【正文】 c regulation stroke volume return to normal in next beat.,第五十四頁，共六十三頁。,11/13/2024,55,Long time high arterial pressure through neural and humoral regulation the stroke volume is maintained at normal level pathogenesis of the cardiovascular system,第五十五頁，共六十三頁。,11/13/2024,56,六、心臟泵血功能(gōngn233。ng)的調(diào)節(jié),(一) 搏出量的調(diào)節(jié) 3：心肌(xīnjī)收縮能力對搏出量的調(diào)節(jié) homeometric autoregulation 心肌通過改變內(nèi)在因素而實現(xiàn)的 活化橫橋的數(shù)目： a) 興奮后胞漿內(nèi)Ca2+濃度(兒茶酚胺) b) 肌鈣蛋白對Ca2+的親和力(鈣增敏劑如茶堿) (2) 肌球蛋白頭部ATP 酶活性(甲狀腺激素、體育鍛煉使其活性?）,第五十六頁，共六十三頁。,11/13/2024,57,六、心臟(xīnz224。ng)泵血功能的調(diào)節(jié),NE,ACh,第五十七頁，共六十三頁。,11/13/2024,58,Action of Sympathetic Stimulation,Sympathetic nerve stimulation increases cardiac contractility. At rest the heart is under sympathetic tone. Noradrenalin enhances calcium entry into cardiac cells. Parasympathetic stimulation has little affect on contractility,第五十八頁，共六十三頁。,11/13/2024,59,六、心臟(xīnz224。ng)泵血功能的調(diào)節(jié),（二）心率對搏出量的調(diào)節(jié) Within physiological limit, the higher the heart rate, the more blood that the heart pump 影響心率的因素： 神經(jīng)(sh233。njīng)：交感(+)、副交感() 體液：E、NE、甲狀腺素、體溫等,第五十九頁，共六十三頁。,11/13/2024,60,1, at rest (without any regulation) 2, during exercise (with humoral and neural regulation),第六十頁，共六十三頁。,11/13/2024,61,You should now be able to,1:draw a diagram showing electrical and mechanical events of the (left) cardiac cycle。 this should be labelled with values for pressure, volume and time 2:explain how pressure changes are generated 3: explain how pressure gradients open and close valves and the generation of heart sounds 4:name and explain the phases of ventricular volume change,第六十一頁，共六十三頁。,11/13/2024,62,You should now be able to,5:define cardiac output and state normal values 6:explain in principle how cardiac output may be measured 7:explain how Starling’s law of the heart using appropriate graphs 8:describle how nerves and hormones modify cardiac function 9:outline the mechanisms which increase cardiac output during exercise 10:describle the physiological consequences of cardiac failure,第六十二頁，共六十三頁。,內(nèi)容(n232。ir243。ng)總結,第三章 血液循環(huán) cardiovascular physiology。心肌的舒縮→室內(nèi)壓變化→瓣膜開閉→血流。（1）：全心舒張期——passive filling。時間：心縮期始——心室(xīnsh236。)開始收縮的標志。特點：頻率較高，持續(xù)時間較短。——衡量代謝提高時心臟射血能力的重要指標。a) 興奮后胞漿內(nèi)Ca2+濃度(兒茶酚胺)。b) 肌鈣蛋白對Ca2+的親和力(鈣增敏劑如茶堿)。神經(jīng)：交感(+)、副交感()。62,第六十三頁，共六十三頁
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