icu天使綜合征-資料下載頁
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【正文】 on feature of these postsynaptic proteins is that they have PSD95/Dlg/ZO1 (PDZ) modular domains for proteinprotein interaction. PDZ domains of these proteins directly recognize the C termini of their target proteins and are believed to play a central role in targeting and clustering of receptors to propersynaptic membranes 2007年UNCDuke大學的研究員建立小鼠模型，發(fā)現(xiàn)AS的小鼠CaMKII含量低下，導致 LongTerm Potentiation (LTP)長時程突觸增強的抑制。對于CaMKII的研究2008年被評為Scientific Highlight of the Year（Nat Neurosci 2007, 10:280282）Motor performance. AS mice show impaired motor performance when tested on the rotarod pared to their wild type littermates, which is rescued when the mice are crossed with mice that have a mutation in the CaMKII gene, resulting in less inhibition of CaMKII (AS/CaMKII305/6 /).Learning of the hidden platform watermaze. Shown are the color plots of the probe trial, indicating where the mice spent most of their swimming time searching for the platform. The black dashed circle indicates the position of the platform during training. AS mice show impaired hippocampal learning at the probe trial given at day 6 pared to their wild type littermates. This impairment in spatial learning is rescued when crossed with the CaMKII305/6 / mice, indicating that this learning deficit is a result of increased phosphorylation of CaMKII at Thr305/306.Synaptic plasticity in AS mice. AS mice show impaired LongTerm Potentiation (LTP), which again is restored to Wildtype level when crossed with CaMKII305/6 / mice.52009年5月，UNCDuke大學的研究員研究暴露光或黑暗中的小鼠視覺區(qū)如何形成新的腦細胞突觸連接。結(jié)果表明，正常小鼠的腦細胞具有可塑性，可適應視覺的變化，而腦細胞Angelman綜合征模型小鼠不能形成新的突觸連接。也就是說，AS的患者因CaMKII變異導致 LTP抑制，進而幼年發(fā)育時期不能形成為新的神經(jīng)突觸。因為神經(jīng)突觸沒有可塑性，所以有嚴重的智力障礙。May 10 in Nature Neuroscience.Pyramidal cell with staining. A type of neuron found in the cerebral cortex, the hippocampus and amygdala. These are the primary excitation units of the prefrontal cortex and spinal tract in mammals. Recent studies on pyramidal neurons have focused on topics ranging from neuroplasticity to cognition. (Credit: Image provided by Ben Philpot lab)寫到這里的感慨，1像天使一樣，純粹的微笑，單純的快樂，這樣的人，任何人都會被吸引吧。但是，如果說代價是永久嚴重的智力障礙，又有幾個人愿意成為那樣的天使？換個角度講，如果人能夠純粹的活著，不去介意一切的煩擾，是不是就會自然呈現(xiàn)出天使的微笑？可是赤子之心，說道容易，能夠做到的，又有幾個? 命運就是讓一個個靈魂逐漸的經(jīng)歷、承受、體驗快樂和悲傷，最后變得成熟而終結(jié)于死亡。如若能放開一切，回歸本源，是否最后剩下的就是這樣透明而純粹的快樂？2惡搞的進一步推理：已知：天使=快樂+愛 語言障礙=無語 癲癇=抽風 智力障礙=傻瓜 天使+病 =快樂+智力障礙+語言障礙+癲癇 合并“天使”“快樂”的同類項可得 有病 =語言障礙+智力障礙+癲癇+愛 ；即：有病 =傻瓜+無語+抽瘋+愛嗯，我承認，我是一個像傻瓜一樣不愛說話，喜歡瘋狂做事內(nèi)心充滿濃濃愛的感動的人。 被你們發(fā)現(xiàn)了，千萬別告訴我老媽。3下次我遇到我討厭的人，我一定這樣說，“你真是個天使”，丫的肯定不知道我是罵人~~~這就是知識的力量（我邪惡的笑）。4有人進一步問我，怎么選題阿寫這些，老實說，我也不知道，剛好找到這張圖，我覺得老米（Michelangelo 米開朗基羅）這話說得挺有道理的。確實，創(chuàng)作只不過是讓自己內(nèi)心地感動通過努力讓其他人也能感知到而已。就用這句話作為這篇文章的結(jié)語。”據(jù)我所感，天使就在大理石里面，我的雕刻只是把它解放出來賦予它自由而已“reference微缺失綜合征的診斷及產(chǎn)前診斷真核生物基因的表達調(diào)控 () () ?=angelman神經(jīng)電生理部分的知識來自論壇，作者beckyhuang bluebacopa chenzhiyong2008 等，不一一注明。.窗體頂端
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