甲狀腺激素和抗甲狀腺藥thyroidhormonesandantithyroid-資料下載頁
2025-07-20 03:22本頁面
【正文】 Iodine and iodide Adverse effects and application notes Acute effects: acute circumscribed edema ， laryngeal edema and apnoea. Chronic toxicity: mouth and throat burning sensation, increase secretion of salivary, eye irritation and so on. Induce dysthyroid and hyperthyroidism after long medication. Iodine could pass into the milk and through placenta, leading to neonat goiter. Pregnant and lactant women shoule take the drug with causious. Allergic and active tuberculosis patients are forbidden to take. Radioactive iodine（ 131I） T1/2 is days Actions 131I could be uptaken by throid , participate in the synthesis of T3, T4 and is stored in follecular colloid. 131I mainly generatesβray （ 99％ ） with average and maximum path of and 2mm respectively. So the irradiation function is limited in the can destroy the glandular an but can seldom destroy the surrounding tissues. Γray generated by 131I accounts for 1％ and can be detected in vitro. It is usually used in the examination of thyroid iodine uptaking function. Radioactive iodine（ 131I） Clinical application ? Thyroid iodine uptake function examination: iodine uptake rate high when hyperthyroid, time of iodine uptake peak antelocation iodine uptake rate low when hypothyroid , time of iodine uptake peak retroposition ? Hyperthyroidism Trace amount could be used in diagnosis of thyroid functional status and thyroid adenoma . Radioactive iodine Adverse effects and application notes Hypothyroidism is the predominant plication. The adverse effects can be reduced by strict dose control and resisted by thyrine. Patients with Total white blood cells less than 3000/mm3 are not suitable to take it. So are pragnant and lactant women, patients younger than 20 years old or with severe liver or kidney deseases. ? receptor blockers ?Valuable adjunctive therapy drugs for hyperthyroidism and thyroid crisis . They could improve symptoms caused by augmented sympathetic activity such as speed up heart rate and increase heart contraction force . They can also reduce the thyroid hormone secretion and T3 synthesis by inhibiting 5`deiodinase . ?Control hyperthyroidism symptoms and can be used in preparation before operation . ? receptor blockers Clinical application ? Adjunctive therapy for hyperthyroidism and hyperthyroidism crisis. Mechanism of pharmacological actions ? Excited sympatheticadrenergic system β1 receptor blockage — heart rate drop Central β receptor blockage — to reduce anxiety β2 receptor on NA energinic peripheral nerve endings presynaptic membrane blockage reduces the release of NA. ? Appropriately reduce T3, T4 secretion. Thanks!
研究報告相關推薦
鄂ICP備17016276號-1