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【正文】 ,張雙慶,李佐剛 UPLC在藥物代謝動力學中的應用[J].中國藥事,2011,(8).[4］劉克辛,韓國柱 臨床藥物代謝動力學〔M〕.北京：科學出版社，2009：5779.[5]賈宜靜,朱海燕,曹紅斌,孟繁蘊 生理藥物代謝動力學模型及其應用[J]. 環(huán)境與健康雜志,2011,(4).[6]Rajman : utility in drug development [J]. Drug Discovervy Today ,2008,13(78) : 341346[7Sami H，Martin B，Robert T，etal. A PBPK modelingbased approach to account for interactions in the health risk assessment of chemical mixtures〔J〕.Toxicology Sciences，2001，63:125131.[8]Robert T，Ginette C，Jules B，et al. Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans〔J〕.Toxicology and Applied Pharmacology，1997，144:120134.[9]ElMasri HA，Kenyon EM. Development of a human physiologically based pharmacokinetic (PBPK) model for inorganic arsenic and its mono and di methylated metabolites〔J〕.Pharmacokinet Pharmacodyn，2008，35：3168.[10]Alan FS，Sastry SI，Panos GG. A generalized physiologically –based toxicokinetic modeling system for chemical mixtures containing metals〔J〕. Theoretical Biology and Medical Modelling，2010，7：17.[11]李敬來,崔孟珣,張振清,阮金秀 藥物代謝動力學在藥物研發(fā)中的意義及作用[J]. 解放軍藥學學報,2010,(3).[12]Rao N, Dvorc ik B, Su ssm an N. A study of the pharm acok inetic in teraction of istradefy lline, a novel therapeu tic for Parkinsonsdisease, and atorvastat in [J] .J Cl in Pharmcol,2008,48(9):10921098[13]S tangier J. Clinical pharmacok in etics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate [ J] . Cl in Pharmacokinet ,2008,47( 5) : 285295[14]劉昌孝. 藥物評價學(第一版)[M].北京: 化學工業(yè)出版社,2006. 162[15]周艷鋼,李煥德 體內藥物代謝研究的意義與應用[J] .中南藥學, 2009,7(1):4550藥物代謝動力學的研究論文 學院：生命科學技術學院學號：20084084141班級：制藥工程一班姓名：周大慶7 /
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