【正文】 版, 上海: 上海醫(yī)科大學出版社,1993, 73~80[7] Liang ZP, Lauterbur P. C. Principles of Magnetic Resonance Imaging[M], New York :IEEE Press, 2000, 17~43[8] Caravan P, Ellison J. J, McMurry T. J, Lauffer R. (III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications[J]. Chem. Rev, 1999, 99: 2293~2352[9] 沈天真, 陳星榮. 中樞神經(jīng)系統(tǒng)計算機體層攝影（CT）和磁共振成像（MRI）[M]. 第一版, 上海: 上海醫(yī)科大學出版社, 1992, 18[10] 羅毅, 卓仁禧, 史玉亭. 磁共振成像造影劑研究的近況[J]. 國外醫(yī)藥（合成藥、生化藥、制劑分冊）.1995, 16(4): 200~208[11] 王毅翔, 沈天真, 陳星榮. 新型磁共振成像造影劑研究動態(tài)[J]. 國外醫(yī)學臨床放射學分冊, 1995, 1(1): 20~22[12] Haustein J, Niedorf H, Krestin G, et al. Renal tolerance of gadoliniumDTPA dimeglumine inpatients with chronic renal failure[J]. Invest. Radiol., 1992, 27(1): 153~156[13] 卓仁禧, 呂正榮, 魏俊發(fā),等. 合成環(huán)狀多氨多羧酸螯合物造影劑的方法[P]. ZL 95 (C07F 19/00)[14] Chang C. A. Magnetic resonance imaging contrast agents: design and physiph ysicochmical properties of gadodiamide[J]. Invest. Radiol., 1993, 28(suppl, 1): 22~27[15] Masui T, Saeed M., Wendland M. F, et al. Occlusive and reperfused myocardial infacts:MR imaging differentiation with nonionic GdDTPABAM[J]. Radiology, 1991, 181(1): 72~83[16] Wedeking P, Sotak C. H., Teleser J, et al. Quantitative dependence of MR signal intensity on tissue concentration of Gd(HPDO3A) in the nephrectomized rat[J]. Magn. Reson. Imag, 1992,10(1): 97~108[17] Cavagna F, Dapa M, Maggioni F, et al. GdBOPTA/Dimeg: experimental disease imaging[J]. Magn. Reson. Med, 1991, 22(3): 329~333[18] Klaassen C, Watkins J. B. Ⅲ, Mechanisms of bile formation, hepatic uptake, and biliary ercretion[J]. Pharmacol. Rev, 1984, 36(1): 1~67[19] SchuhmannGiampieri G, SchmittWillich H, Negishi W. R, et al. Preclnical evaluation of GdEOBDTPA as a contrast agent in MR imaging of the hepatobiliary system[J]. Radiology, 1993, 183(1): 59~64[20] Heinz G, Erich K, Bernol R, et al. Preparation of DTPA monoamides and their metal plexes as contrast agents for NMR imaging[J]. Eur. Pat. Appl. EP, 450742, 19911009, 16~17[21] Desreux J. F, Tweedle M. F, Ratsep P. C, et al. Preparation of hepatobiliary tetraazama crocylic magnetic resonance contrast agents[P]. US, 5358704(1994)[22] Rummeny E, Ehrenheim C, Gehl H. B, et al. ManganeseDPDP as a hepatobiliary contrast agent in the magnetic resonance imaging of liver tumors: results of clinical phase Ⅱ. Trials in Germany including 141 patients[J]. Invest. Radiol, 1991, 26(Suppl 1): 124~125[23] Cynthia R., Rogers J, Arias I. M, et Nanoparticles: New Contrast Agents for Magnetic Resonance Imaging[J]. J. Am. Chem. Soc., 2000, 122: 8940~8945[24] 孫國英, 馮江華, 景鳳英, 裴奉奎. 以阿拉伯半乳聚糖為載體的磁共振成像造影劑的研究[J]. 高等學?；瘜W學報, 2002, 23(10): 1837~1841[25] Young S. W, Sidhu M. K, Qing F, et al. Preclinical evaluation of gadolinium(Ⅲ) texaphyrin plex: A new paramagnetic contrast agent for magnetic resonance imaging[J]. Invest. Radiol, 1994, 29(3): 330~338[26] Citro G, Szczylik C, Demeure P, et al. Inhibition of leukemia cell proliferation by folic acidpolysinemediated introduction of cmyb antisense oligodeoxynucleotides into HL60 cells[J]. Br. J. Cancer, 1994, 69(3): 463~467[27] Turek , Leamon , Low P. S. Endocytosis of folateprotein conjugates: ultrastructural localization in KB cells[J]. J. Cell .Sci, 1993, 106: 423~430[28] Knopp M. V, TenggKobligk H. V, Floemer F, et al. Contrast agents for MRA:future directions[J]. J. Magn. Reson. Imag, 1999, 10: 314~316[29] 鄢國平, 卓仁禧. 磁共振成像造影劑的研究進展[J]. 科學通報, 2001, 46(7): 531~538[30] 魏俊發(fā), 何地平, 潘娓婕, 等. 雙吡哆基二乙三胺五乙酸雙酰胺和雙酯衍生物及其釓螯合物的合成、表征與弛豫性能[J]. 陜西師范大學學報(自然科學版), 2001, 29(3): 70~75致謝本論文是在導師XXX老師的悉心指導下完成的，導師嚴謹?shù)闹螌W態(tài)度、豐富的專業(yè)知識、勤勤懇懇的工作作風和執(zhí)著的創(chuàng)新探索精神令我深受教益，終生難忘。導師在實驗過程中給予我極大的支持、鼓勵和幫助。在此，謹向他表示崇高的敬意和衷心的感謝！祝老師在以后的工作、生活中能夠身體健康，一切順利！另外，還要感謝實驗室的幾位師哥師姐在實驗期間給予的幫助和指導。感謝我的同學實驗中一直給予的支持和無私幫助！感謝他在論文寫作過程中給予的幫助!還要感謝各位評審老師在百忙之中，抽時間來審評我的實驗和論文。感謝這期間一直給與我?guī)椭陌嚅L同學及全班同學，祝愿他們在新的學校、崗位心想事成，萬事如意！最后，感謝我宿舍兄弟們的支持!感謝我的父母，感謝他們多年的培養(yǎng)和教