關(guān)于氨基酸和神經(jīng)肽與疼痛關(guān)系的研究-資料下載頁(yè)
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【正文】 ? Does not act on the classic opiate receptors ? Does not act on ORL1 receptor 痛穩(wěn)素受體 (?) 不作用于典型的阿片受體 不作用于阿片孤兒受體 (ORL1 )受體 The role of the ORL1 receptor in the modulation of spinal Neurotransmission by nociceptin / orphanin FQ and nocistatin Ahmadi S, Liebel JT, Zeilhofer HU. Eur. J. 。412:3944 Modulation of synaptic transmission by nociceptin / orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin / orphanin FQ receptor Ahmadi S, Kotalla C, Guhring H, Takeshima H, Pahl A, Zeilhofer HU Molecular Pharmacology 2022。59:6128 Possible pathways involved in Noc/OFQinduced hyperalgesia and allodynia in the spinal cord Ito S et al. 2022 Clinical Significance ? Antinociceptive Responses Produced by Human Putative Counterpart of Nocistatin Minami T et al Br J Pharmacol 1998。 124: 101618 ? Identification of Nocistatin in Human, Rat and Mouse Brain and Human Cerebrospinal Fluid Lee TL et al. NeuroReport 1999。 10: 1537 臨床意義 對(duì)抗由人們公認(rèn)的痛穩(wěn)素類似體所引起的傷害性反應(yīng) 人 ,大鼠 ,小鼠大腦及人腦脊液中痛穩(wěn)素的鑒別 H uman N oc is t atin and N oc ic e pt inRR MPRVRSLFQEQEEPEPGMEEAGEMEQKQLQ KR FGGFTGARKSARKLANQ KRH u ma n1 4 8KR MPRVRSLVQVRDAEPGADAEPGADAEPGADDAEEVEQKQLQ KR FGGFTGARKSARKLANQ KRMo u se1 5 9KR MPRVRSVVQARDAEPEADAEPVADEADEVEQKQLQ KR FGGFTGARKSARKLANQ KRR a t1 5 3KR MPRVRSLFQRQ KR TEPGLEEVGEIEQKQLQ KR FGGFTGARKSARKLANQ KRBo vi n e1 4 8No c ic e p ti n96969696No c is ta ti nNo c is ta ti nIdentification of Nocistatin in Human, Rat and Mouse Brain and Human Cerebrospinal Fluid Lee TL, Fung F, Tachibana S et al. NeuroReport 1999。 10: 1537 ? Present in human nervous system ? Different NST forms ? Animal models 人 ,大鼠 ,小鼠大腦及人腦脊液中痛穩(wěn)素的鑒別 存在于人類的神經(jīng)系統(tǒng)中 痛穩(wěn)素的不同結(jié)構(gòu) 動(dòng)物模型 Lee TL et al. 1999 Pathophysiological roles of the two isoforms of nocistatin in pain perception: parison of bioactivities between nocistatin17 and nocistatin30 Meng MJ. 2022。 Thesis, Master of Clinical Science. National University of Singapore ? Tested against NCP induced allodynia amp。 hyperalgesia in mice. ? NST17 has weaker amp。 shorter duration of action against NCP as pared to NST30. 痛穩(wěn)素的兩種對(duì)碘氧基苯甲醚在疼痛感知中的病理生理作用 : 痛穩(wěn)素 17與痛穩(wěn)素 30的生物活性比較 NST ? Antinociceptive neuropeptide (normalize nociceptive threshold) ? Supraspinal and spinal sites ? Does not act on opioid or ORL1 receptors ? Present in human brain and CSF ? Other central and peripheral effects (. learning and memory) 抗疼痛反應(yīng)的神經(jīng)肽 (使疼痛反應(yīng)閾值正?；?) 神經(jīng)索和脊髓 不作用于阿片受體和 ORL1受體 存在于人腦和腦脊液中 其他的中樞和外周作用 (如學(xué)習(xí)和記憶 ) Nocistatin amp。 Nociceptin ? Nociceptin ligand for orphan opioid receptor ? Nocistatin – functional antagonist ? Identify precursors ? Sequence bioactive derivatives ? Establish the active fraction OkudaAshitaka E, Tachibana S et al, Nocistatin, a peptide that blocks nociceptin action in pain transmission Nature 1998 Lee TL, Tachibana S. Nocistatin – a new antinociceptive peptide. Regional Anesthesia amp。 Pain Medicine 2022 Involvement of endogenous orphanin FQ in electroacupuncture induced analgesia. Tian JH, Xu W, Zhang W et al. NeuroReport. 1997。8:497500 Endogenous orphanin FQ: evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture Tian JH, Zhang W, Fang Y et al. Br J Pharmacol 1998。 124:216 Functional studies using antibodies against orphanin FQ / nociceptin Tian JH, Han JS. Peptides. 2022。 21:104750 NST (future) ? NST receptor(s) ? Antagonists / agonists ? Correlate with specific disease state 痛穩(wěn)素 (前景 ) 痛穩(wěn)素受體 拮抗劑 /激動(dòng)劑 與特異疾病的相關(guān)性
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