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間無關(guān),第二十二頁,共四十三頁。,每日劑量相同,一次與多次服藥 甲狀腺內(nèi)MMI濃度(n243。ngd249。)無差異,23,黃國良等,中華(Zhōnghu225。)內(nèi)分泌化學雜志 1992,8∶17,第二十三頁,共四十三頁。,甲巰咪唑(mī zu242。) :ANCA相關(guān)性血管炎危險顯著低于PTU,Gao Y, Guo XH, et al. The prevalence and target antigens of antithyroid drugs induced antineutrophil cytoplasmic antibodies(ANCA) in Chinese patients with hyperthyroidism. Endocrine Research. 2004。30(2):205213,第二十四頁,共四十三頁。,甲巰咪唑治療GD 發(fā)生(fāshēng)MPOANCA的比例低于PTU,女性(nǚx236。ng),男性(n225。nx236。ng),停藥的女性,停藥的男性,Sato H, et al. High prevalence of antineutrophil cytoplasmic antibody positivity in childhood onset graves’ disease treated with propylthiouracil. J Clin Endocrinol Metab. 2000。85:42704273,治療前 PTU組 MMI組 n=16 n=25 n=10,髓過氧化物酶特異性抗中性粒細胞胞質(zhì)抗體(EU),第二十五頁,共四十三頁。,PTU有其特殊(t232。shū)的優(yōu)點,PTU600mg/d可抑制T4向T3的轉(zhuǎn)變,用于甲亢危象的搶救(qiǎngji249。); PTU透過胎盤少,用于妊娠甲亢。,第二十六頁,共四十三頁。,甲巰咪唑(mī zu242。)ANCA相關(guān)血管炎危險顯著低于PTU,Gao Y, Guo XH, et al. The prevalence and target antigens of antithyroid drugs induced antineutrophil cytoplasmic antibodies(ANCA) in Chinese patients with hyperthyroidism. Endocrine Research. 2004。30(2):205213,第二十七頁,共四十三頁。,哪個(nǎ ge)藥物最好? MMI vs. PTU,Copper DS, Rivkees SA. Putting Propylthiouracil in Perspective[J]. J Clin Endocrinol Metab, June 2009, 9