中心動脈壓與血管功能(編輯修改稿)
2025-06-22 01:16 本頁面
【文章內(nèi)容簡介】 Glucose intolerance and arterial stiffness The Hoorn Study 243 129 256 60 55 50 45 40 120 74 125 34 33 32 31 30 261 170 188 Total arterial compliance (SV/carotid PP, ml/mmHg) Transmission time from carotid artery to femoral artery (msec) Augmentation index (%) * * * * Control Impaired glucose tolerance Type 2 DM Change in HR (bpm) 10 8 6 4 2 0 Change in AI (%) 1 0 Change in PWV (m/sec) 5 4 3 2 1 0 1 2 3 4 Asmar RG, et al. Hypertension. 2022。38:922 * ** Mean177。SD. *p, ** p vs atenolol. Effect of antihypertensive drugs on brachial BP and central BP Diastolic BP on brachial artery was matched for 1 year Perindopril / indapamide (n=204) atenolol (n=202) Am J Hypertens 17:118–123, 2022 70 80 90 100 110 120 130 140 150 160 170 Placebo * * * * * * * * * * * * Blood pressure (mmHg) peripheral central 32 elderly hypertensive patients (age 6580) were treated for 4 weeks each drugs in double blind and crossover fashion. Effect of antihypertensive drugs double blind and crossover study ACE inhibitor bblocker Ca channel blocker diuretics Effect of antihypertensive drugs on AI and central BP AI Central BP diuretics ↓→ ↓ bblocker ↑→ ↓→ ACE inhibitor/ARB ↓ ↓↓ Ca channel blocker ↓ ↓↓ CAF201。 : 肱動脈和中心動脈 收縮壓 肱動脈收縮壓 平均差異 (AUC)= 氨氯地平 阿替洛爾 P=.07 P.0001 0 1 2 3 4 5 6 AUC 115 140 135 130 125 120 mm Hg 中心動脈收縮壓 平均差異 (AUC)= 時(shí)間 (年 ) 阿替洛爾 86 243 324 356 445 372 462 270 339 128 85 1031 氨氯地平 88 248 329 369 475 406 508 278 390 126 101
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