阿司匹林相關(guān)潰瘍ppt課件(編輯修改稿)
2025-06-03 06:32 本頁面
【文章內(nèi)容簡介】 ? ? COX2 selective NSAIDs Vane amp。 Botting 1995 Aspirin inhibit the COX enzyme, which exists in two forms Wallace et al 2022 胃粘膜損傷需要 COX1和 COX2同時(shí)被抑制 Gastric damage score (%) 0 5 10 15 * p Vehicle Celecoxib SC560 Indo methacin Celecoxib + SC560 * * increase neutrophil–endothelial adhesion Aspirin Decreased prostaglandin, increased tumour necrosis factor Increased neutrophil– endothelial adhesion Capillary obstruction Neutrophil release of proteases and oxygenderived free radicals Ischaemic/hypoxic cell injury Endothelial and epithelial injury Mucosal ulceration Wallace et al 1997 Elliott et al 1996 intraduodenal indomethacin, 40 mg/kg intraduodenal saline Total haemorrhagic mucosal area (%) Gastric luminal pH 0 1 2 3 4 5 阿司匹林所致胃腸粘膜損傷為 PH依賴性 胃酸在 NSAID胃腸粘膜損傷中占重要作用 Acidic environment Bicarbonate layer Ionic gradient Gastric acid NSAIDs Pepsin Surface epithelial cells Mucus layer Neutral environment Mucosal blood supply Alkaline environment Prostaglandin production Bicarbonate production
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