阿司匹林相關潰瘍ppt課件-展示頁
2025-05-16 06:32本頁面
【正文】 副作用 阿斯匹林引起消化性潰瘍 Douthwaite AH amp。 Botting 1995 Aspirin inhibit the COX enzyme, which exists in two forms Wallace et al 2022 胃粘膜損傷需要 COX1和 COX2同時被抑制 Gastric damage score (%) 0 5 10 15 * p Vehicle Celecoxib SC560 Indo methacin Celecoxib + SC560 * * increase neutrophil–endothelial adhesion Aspirin Decreased prostaglandin, increased tumour necrosis factor Increased neutrophil– endothelial adhesion Capillary obstruction Neutrophil release of proteases and oxygenderived free radicals Ischaemic/hypoxic cell injury Endothelial and epithelial injury Mucosal ulceration Wallace et al 1997 Elliott et al 1996 intraduodenal indomethacin, 40 mg/kg intraduodenal saline Total haemorrhagic mucosal area (%) Gastric luminal pH 0 1 2 3 4 5 阿司匹林所致胃腸粘膜損傷為 PH依賴性 胃酸在 NSAID胃腸粘膜損傷中占重要作用 Acidic environment Bicarbonate layer Ionic gradient Gastric acid NSAIDs Pepsin Surface epithelial cells Mucus layer Neutral environment Mucosal blood supply Alkaline environment Prostaglandin production Bicarbonate production
教學課件相關推薦
鄂ICP備17016276號-1