基于異腈的多組分反應構(gòu)建功能化雜環(huán)化合物骨架(編輯修改稿)
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【文章內(nèi)容簡介】 Hz), (s, 2H), (s, 1H), (s, 3H), (s, 3H), (s, 3H), (s, 9H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , ..( cm1) 3256,3163,2951,2213,1745,1662,1445,1297,1108,1078.HRMS (ESI) m/z Calc. Found .Dimethyl6(1benzyl5methoxy1Hindol3yl)5cyano2(cyclohexylamino)4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (d, 1H, J = 8 Hz), (s, 1H), (d, 1H, J = 12 Hz), (m, 5H) , (s, 1H), (d, 1H, J = 8 Hz), (s, 2H), (s, 1H), (s, 3H), (s, 3H), (s, 3H), (m, 2H), (m, 2H), (m, 1H), (m, 6H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , , , .IR(cm1) 3268,3114,2935,2853,2210,1743,1675,1532,1453,1380,1298,1212,1082.HRMS (ESI) m/z Calc. Found .Dimethyl6(1benzyl5bromo1Hindol3yl)2(tertbutylamino)5cyano4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (s, 1H), (s, 1H), (s, 1H), (d, 1H, J = 8 Hz), (d, 1H, J = 8 Hz) , (m, 5H), (s, 2H), (s, 1H), (s, 3H), (s, 3H), (s, 9H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , IR(cm1) 3255,3165,2962,2204,1740,1658,1527,1445,1360,1294,1179,1069.HRMS (ESI) m/z Calc. Found .Dimethyl6(1benzyl5bromo1Hindol3yl)5cyano2(cyclohexylamino)4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (d, 1H, J = 8 Hz), (s, 1H), (s, 1H), (d, 1H,J = 8 Hz), (d, 1H, J = 8 Hz) , (m, 5H), (s, 2H), (s, 1H), (s, 3H), (s, 3H),(m, 2H), (m, 2H), (m, 1H), (m, 6H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , , .IR(cm1) 3258,3126,2855,2203,1739,1643,1525,1449,1371,1277,1186,1077.HRMS (ESI) m/z Calc. Found .Dimethyl2(tertbutylamino)5cyano6(1(4(trifluoromethyl)benzyl)1Hindol3yl)4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 300 MHz) δ (s, 1H), (s, 1H), (m, 4H), (d, 2H, J = 6 Hz), (m, 2H) , (s, 2H), (s, 1H), (s, 3H), (s, 3H), (s, 9H).13C NMR (DMSO, 100 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , .IR(cm1) 3260,3177,2965,2213,1742,1679,1537,1442,1321,1177,1129,1070.HRMS (ESI) m/z Calc. Found .Dimethyl5cyano2(cyclohexylamino)6(1(4(trifluoromethyl)benzyl)1Hindol3yl)4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (d, 1H, J = 8 Hz), (s, 1H), (d, 1H, J = 8 Hz), (d, 2H, J = 8 Hz) , (d, 1H, J = 8 Hz), (d, 2H, J = 8 Hz) , (m, 2H), (s, 2H), (s, 1H), (s, 3H), (s, 3H),(m, 2H), (m, 2H), (m, 1H), (m, 6H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , , , .IR(cm1) 3255,3168,2934,2209,1744,1634,1538,1448, 1305,1176,1072.HRMS (ESI) m/z Calc. Found .Dimethyl6(1(3bromobenzyl)1Hindol3yl)2(tertbutylamino)5cyano4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (s, 1H), (s, 1H), (dd, 2H, J = 8,8 Hz), (m, 2H), (m, 4H), (s, 2H), (s, 1H), (s, 3H), (s, 3H), (s, 9H).13C NMR (DMSO, 100 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , , , .IR( cm1) 3248,3166,3116,2963,2208,1754,1677,1531,1444,1387,1300,1176,1085.HRMS (ESI) m/z . Calc. Dimethyl6(1(3bromobenzyl)1Hindol3yl)5cyano2(cyclohexylamino)4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (d, 1H, J = 8 Hz), (s, 1H), (d, 1H, J = 8 Hz), (d, 1H, J = 8 Hz), (s, 1H), (m, 1H), (m, 4H), (s, 2H), (s, 1H), (s, 3H), (s, 3H), (m, 2H), (m, 2H), (m, 1H), (m, 6H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , ,
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鄂ICP備17016276號-1