基于異腈的多組分反應(yīng)構(gòu)建功能化雜環(huán)化合物骨架(文件)
【正文】 H, J = 8 Hz), (s, 1H), (d, 1H, J = 8 Hz), (d, 2H, J = 8 Hz) , (d, 1H, J = 8 Hz), (d, 2H, J = 8 Hz) , (m, 2H), (s, 2H), (s, 1H), (s, 3H), (s, 3H),(m, 2H), (m, 2H), (m, 1H), (m, 6H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , , , .IR(cm1) 3255,3168,2934,2209,1744,1634,1538,1448, 1305,1176,1072.HRMS (ESI) m/z Calc. Found .Dimethyl6(1(3bromobenzyl)1Hindol3yl)2(tertbutylamino)5cyano4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (s, 1H), (s, 1H), (dd, 2H, J = 8,8 Hz), (m, 2H), (m, 4H), (s, 2H), (s, 1H), (s, 3H), (s, 3H), (s, 9H).13C NMR (DMSO, 100 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , , , .IR( cm1) 3248,3166,3116,2963,2208,1754,1677,1531,1444,1387,1300,1176,1085.HRMS (ESI) m/z . Calc. Dimethyl6(1(3bromobenzyl)1Hindol3yl)5cyano2(cyclohexylamino)4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (d, 1H, J = 8 Hz), (s, 1H), (d, 1H, J = 8 Hz), (d, 1H, J = 8 Hz), (s, 1H), (m, 1H), (m, 4H), (s, 2H), (s, 1H), (s, 3H), (s, 3H), (m, 2H), (m, 2H), (m, 1H), (m, 6H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , , , , , .IR (cm1) 3250,3130,2934,2856,2200,1740,1675,1525,1447, 1289,1182,1082.HRMS (ESI) m/z Calc. Found .Diethyl2(tertbutylamino)5cyano6(1methyl1Hindol3yl)4Hpyran3,4dicarboxylateMP 119121 oC1H NMR (DMSO, 400 MHz) δ (s, 1H), (s, 1H), (m, 2H), (t, 1H, J = 8 Hz), (t, 1H, J = 8 Hz), (s, 1H), (m, 4H), (s, 3H), (s, 9H), (t, 3H, J = 6 Hz), (t, 3H, J = 6 Hz).13C NMR (DMSO, 100 MHz) δ , , , , , , , , , , , , , , , , , , , , , , .IR(cm1) 3269,3118,2973,2209,1740,1674,1529,1434, 1380,1211,1041.HRMS (ESI) m/z Calc. Found .Diethyl5cyano2(cyclohexylamino)6(1methyl1Hindol3yl)4Hpyran3,4dicarboxylateMP 119123 oC1H NMR (DMSO, 400 MHz) δ (d, 1H, J = 8 Hz), (s, 1H), (d, 1H, J = 8 Hz), (d, 1H, J = 8 Hz), (t, 1H, J = 6 Hz), (t, 1H, J = 6 Hz), (m, 5H), (s, 3H), (m, 2H), (m, 2H), (m, 1H), (m, 12H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , .IR( cm1) 3249,3162,2931,2860,2203,1750,1631,1527,1449, 1364,1171,1088.HRMS (ESI) m/z Calc. Found .Diethyl6(1benzyl1Hindol3yl)2(tertbutylamino)5cyano4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (s, 1H), (s, 1H), (d, 1H, J = 8 Hz), (m, 7H), (s, 2H), (s, 1H), (m, 4H), (s, 9H), (t, 3H, J = 6 Hz), (t, 3H, J = 6 Hz).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , , , .IR(cm1)3259,3163,2977,2207,1739,1667,1524,1447, 1377,1288,1186,1078.HRMS (ESI) m/z Calc. Found .Diethyl6(1benzyl1Hindol3yl)5cyano2(cyclohexylamino)4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 400 MHz) δ (d, 1H, J = 8 Hz), (s, 1H), (d, 1H, J = 8 Hz), (d, 1H, J = 8 Hz), (m, 7H), (s, 2H), (s, 1H), (m, 4H), (m, 2H), (m, 2H), (m, 1H), (m, 12H).13C NMR (DMSO, 75 MHz) δ , , , , , , , , , , , , , , , , , , , , , , , , , , , .IR(cm1) 3283,3104,2931,2206,1744,1675,1529,1449, 1383,1283,1177,1078.HRMS (ESI) m/z Calc. Found .Diethyl2(tertbutylamino)5cyano6(1hexyl1Hindol3yl)4Hpyran3,4dicarboxylateMP oC1H NMR (DMSO, 300 MHz) δ (s, 1H), (s, 1H), (m, 2H), (m, 2H), (t, 2H, J = 6 Hz), (s, 1H), (m, 4H), (s, 9H), (m, 14H), (t, 3H, J = 6 Hz).13C NMR (DMSO, 100 MHz) δ , ,
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鄂ICP備17016276號-1