炎癥性腸病ppt課件(編輯修改稿)
2025-02-11 20:53 本頁面
【文章內容簡介】 nteric flora T cell activation Proliferation Apoptosis Defective apoptosis Crohn’s disease Proliferation Apoptosis T cell activation Increased apoptosis Controlled inflammation T cell activation Proliferation Apoptosis Normal apoptosis Physiological inflammation Pathogens Dietary antigens Crohn’s disease Only small bowel 25 – 30 % Only colon 20 – 25 % Anorectal disease (anal fistulae, ascesses) 30 – 40 % Small bowel and colon 40 – 55 % Esophagus Stomach Duodenum 3 – 5 % Involvement of rectum 11 – 26 % Distribution of inflammatory bowel diseases Proctosigmoiditis 30 – 50 % (Sub)total colitis15 – 20 % ?back wash ileitis“ Ulcerative colitis UC UC UC CD 臨床表現 ?腹痛 ?腹瀉、血便 ?腹部包塊 ?體重下降 ?瘺管形成 ?肛周膿腫 ?發(fā)熱 ?腸外表現 ? “ 非典型 ” 改變：阿弗他潰瘍 診斷手段 常規(guī)大腸鏡、鋇灌腸 ? “ 典型 ” 改變：節(jié)段性病灶、縱行潰瘍、鵝卵石 樣改變，腸腔狹窄 Endoscopy Flat ulcers Ulcerative colitis Crohn180。s disease Deep longitudinal ulcers, cobblestone mucosa Crohn180。s Disease Typical linear ulcers in the sigmoid (left) and aphtoid lesion in normal mucosa (right) Histology U M SM M SM F Ulcerative colitis ?Mucosal inflammation only (M) ?Ulcers (U) Crohn180。s disease ? Transmural inflammation mucosa (M) and submucisa (SM) ? Ulcers ? Fissures (F) Histology Ulcerative colitis ? Cr
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