《炎癥性腸病》ppt課件-文庫吧
2024-12-31 20:53 本頁面
【正文】 eudomembranous colitis） vascular （ ischemic colitis, radiation exposure ） systemic （ collagen disease、 uremic toxic syndrome） Idiopathic Crohn’s disease Ulcerative Colitis others（ Beh231。et disease、 nonspecific multiple ulcers in small bowel） Inflammatory Bowel Disease： IBD ？ systemic disease infection drug mechanical stimulation vascular Pathophysiological Background of IBD Geic factors Environmental factors Immunological abnormalities Intestinal inflammation Enteric flora Environmental factors Genes Immune system Smoking Diet Drugs Geography and social status Stress Microbes and enteric flora Permeability Appendectomy Inflammatory bowel disease Hygiene hypothesis: postulated mechanisms “Clean” lifestyle Matricardi amp。 Bonini Clin Exp Allergy 2022 “Dirty” lifestyle High allergy Low allergy Th1 Th2 Hay fever Asthma Atopic eczema Food allergy Low microbial exposure Weak immune stimulation Crohn’s disease Strong immune stimulation Weak regulatory work: low IL10 and TGFb High microbial exposure A. Levine, 2022 Acute inflammation (Host defense) Physiologic/”controlled” inflammation Return to tolerance Pathologic/uncontrolled inflammation (IBD) Loss of tolerance Patterns of intestinal immune responses Food Flora E
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