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conds = x 1027 years age of universe ? This is known as the Levinthal paradox. Models of Protein Folding Framework model of protein folding Supported by experimental observation of rapid formation of secondary structure during protein folding process N C Framework model of protein folding N C Formation of individual secondary structure elements Framework model of protein folding N C Coalescence and rearrangement of individual secondary structure elements Nuclear condensation model N C Supported by protein engineering studies and various theoretical calculations Nuclear condensation model N C Formation of a nucleus of hydrophobic residues Nuclear condensation model N C Expansion of nucleus Framework and Condensation models are extremes on a continuum Framework (or diffusioncollision): 2186。 structure forms independently and “dock” to form 3186。 structure Nucleation condensation: Concerted consolidation of 2186。 and 3186。 structure as nucleus expands Condensation when 2186。