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? 瑞典研究 2( 114,841例患者)證實(shí)了上述研究的結(jié)論,甘精胰島素與其它胰島素相比乳腺癌的相對風(fēng)險(xiǎn)為 ( 95% 可信區(qū)間 ), 但是對于其它類型的腫瘤沒有發(fā)現(xiàn)顯著聯(lián)系。 ? 蘇格蘭研究 3( 49,197例患者)顯示,在單獨(dú)應(yīng)用甘精胰島素的患者,甘精胰島素與其它胰島素相比所有癌癥的風(fēng)險(xiǎn)有輕微顯著增加,但是作者將這種小幅度增加歸因?yàn)槿巳旱姆峙淦小? ? 英國研究 4( 62,809例患者)沒有證實(shí)甘精胰島素與其它胰島素相比與癌癥風(fēng)險(xiǎn)增加相關(guān),但是顯示了二甲雙胍在癌癥發(fā)生過程中的保護(hù)作用。 1. Hemkens et al. Diabetologia. 2022。52(9):173244. 2. Jonasson et al. Diabetologia. 2022。52(9):174554. 3. Colhoun et al. Diabetologia. 2022。52(9):175565. 4. Currie et al. Diabetologia. 2022。52(9):176677. Possible link between insulin Glargine and cancer prompts urgent call for more research The European Association for the Study of Diabetes (EASD) has made an urgent call for more research into a possible link between use of insulin glargine (an insulin analogue) and increased risk of cancer, following evidence from studies in Germany, Sweden and Scotland. The International Diabetes Federation understands the concern about the Diabetelogia study findings but urges the diabetes munity to wait for the current scientific information to be released and calls for urgent further scientific studies to be undertaken in other countries. 緊急號召進(jìn)一步的研究 促有絲分裂能力增強(qiáng)是否會促進(jìn) 細(xì)胞增殖,尤其是癌細(xì)胞增殖? 胰島素類似物刺激人乳腺上皮細(xì)胞系 增殖的相關(guān)信號傳導(dǎo)通路分析