胰島素類似物的分子安全性-全文預(yù)覽
【正文】 系 在含 10%患者血清的 培養(yǎng)液中孵育 72小時 取患者血清樣本 治療 1周以上 Mayer amp。52(9):176677. Possible link between insulin Glargine and cancer prompts urgent call for more research The European Association for the Study of Diabetes (EASD) has made an urgent call for more research into a possible link between use of insulin glargine (an insulin analogue) and increased risk of cancer, following evidence from studies in Germany, Sweden and Scotland. The International Diabetes Federation understands the concern about the Diabetelogia study findings but urges the diabetes munity to wait for the current scientific information to be released and calls for urgent further scientific studies to be undertaken in other countries. 緊急號召進(jìn)一步的研究 促有絲分裂能力增強(qiáng)是否會促進(jìn) 細(xì)胞增殖，尤其是癌細(xì)胞增殖？ 胰島素類似物刺激人乳腺上皮細(xì)胞系 增殖的相關(guān)信號傳導(dǎo)通路分析 ★ vs 人胰島素 ★★ vs 牛胰島素 , p＜ 優(yōu)泌樂 牛胰島素 短效人胰島素 來得時 諾和平 諾和銳 n=20 0 對照 ★ ★ ★ 增殖的倍數(shù) (與對照組相比) 150nM ★ ★ ★ ★ ★ ★ 15nM ★ ★ ★ Shukla et al. EndocrineRelated Cancer 2022。 1. Hemkens et al. Diabetologia. 2022。 日劑量更高時，與人胰島素相比相對風(fēng)險進(jìn)一步增加。在骨肉瘤細(xì)胞中應(yīng)用 TdR摻入法分析顯示 HOE901的促有絲分裂活性比人胰島素增高 3－ 5倍 …這些體外研究的發(fā)現(xiàn)與人類臨床應(yīng)用之間的顯著性和相關(guān)性有待研究
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