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40% 0 2 4 6 8 AFASAK 58% 7– 81 SPAF 67% 27– 85 BAATAF 86% 51– 96 CAFA 42% 68– 80 SPINAF 79% 52– 90 TOTAL 68% 50–79 p p p p p p Controls Warfarin 二、華法林的評估 : 相對危險性減少 68% 21 華 法林 主要出血 安慰 劑 顱 內(nèi)出血 AFASAK SPAF BAATAF SPINAF CAFA EAFT 年發(fā)生率 (%) :出血風險高。顱內(nèi)出血風險較安慰劑組高 , 有些腦出血為致命性 二、華法林的評估 22 Time in target range (%) 0 20 40 60 80 100 USA Canada France Italy Spain INR INR – INR Ansell J et al. J Thromb Thrombolysis 2020。23:83–91 The predominant vitamin K antagonist (VKA) in use was warfarin in the US, Canada and Italy。 acenocoumarol in Spain。 and fluindione in France。 INR = international normalized ratio : INR,治療窗窄 Odds Ratio 0 INR —中風 —顱內(nèi)出血 Fuster et al. J Am Coll Cardiol. 2020。38:12311266. 缺血性中風與顱內(nèi)出血 校正的 OR與抗凝強度的關(guān)系 24 Time in target range (%) 0 20 40 60 80 100 USA Canada France Italy Spain INR INR – INR Ansell J et al. J Thromb Thrombolysis 2020。23:83–91 The predominant vitamin K antagonist (VKA) in use was warfarin in the US, Canada and Italy。 acenocoumarol in Spain。 and fluindione in France。 INR = international normalized ratio : (30%)達不到目標值 事件 , %/年 事件 Poor control group (n = 1990) Moderate control group (n = 1207) P 卒中或體栓塞