室性心律失常藥物治療的現(xiàn)狀與挑戰(zhàn)pharmacologicaltherapy(已修改)
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【正文】 室性心律失常藥物治療的現(xiàn)狀與挑戰(zhàn) Pharmacological Therapy of Ventricular Arrhythmia Current Status and Challenge 南京醫(yī)科大學(xué)第一附屬醫(yī)院心內(nèi)科 江 蘇 省 心 肺 疾 病 研 究 所 江蘇省心血管病臨床醫(yī)學(xué)中心 曹克將 Sudden Cardiac Death A Major Public Health Problem 1/2 of all cardiac deaths 1/7 of all deaths Leading Causes of Death in the US SCD is a leading cause of death in the ., second to all cancers bined Sudden Cardiac Death (SCD) Septicemia Nephritis Alzheimer’s Disease Influenza/Pneumonia Diabetes Accidents/Injuries Chronic Lower Respiratory Diseases Cerebrovascular Disease Other Cardiac Causes All Cancers 20% 25% National Vital Statistics Report, Vol 49 (11), Oct. 12, 2020 Statespecific mortality from sudden cardiac death – United States 1999. MMWR. 2020,51:123126 15% 10% 5% 0% ? At least 335,000 /y SCD in the . ? Only 5 to 10% survive after first episode of SCD ? Roughly 2/3 of SCD outofhospital ? At least 540,000 /y SCD in China SCD Survival amp。 Mortality Data Seidl K, Senges J. Card Electrophysiol Rev. 2020。7:513 Heart Disease and Stroke Statistics — 2020 Update. AHA. Crespo EM, Kim J, Selzman KA. Am J Med Sci. 2020。329:238246 Zheng ZJ, et al. Circulation. 2020。104:21582163 Zipes, DP, et al. 2020 ACC/AHA/ESC Practice Guidelines 5. Circulation. 2020。114。385484 Arrhythmic Cause of SCD Albert CM. Circulation 2020,107:20962101 12% Other Cardiac Cause 88% Arrhythmic Cause Bradycardia 17% Primary VF 8%
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