安全輸血(3)-在線瀏覽
2025-02-07 19:42本頁面
【正文】 t R H D all e l e s i n o t h er p o p u l a t i o n g ro u p s i s o n l y p o rt i al l y res o l re d .(D e l J a p an e s e) E x o n 4 P CR p r o d u c t RH D : 4 9 8 b p RH D ψ : 5 3 5 b p RH C: 3 2 0 b p i n t r o n 2 RH c: 1 7 7 b p e x t o n 2 Vox Sang 2023。78(suppl 2):083089 Site Directed Mutagenesis of the Human RhD Antigen: Molecular Basis of D Epitopes. Neil Liu...Douglas Voak. Dnegative phenotypes_two major mecharisms_at the genomic level. RHD gene deletion RHDψ(psendogene):37bp insertion and nonsense mutation in RHDgene. All weak D phenotypes:caused by coding region regions in the RHDgene. allered D antigen expression (lack some D epitopes) (previous dogma that weak D phenotype individuals have merely quartitative but not qualitative differerces in RhD antigon is incorrect.) Partial D of partial D phenotypes are “Knockonts” where loss of epitopes. partial D phenotypes involve just one amino acid change. phenotypesmall number of D epitopes. RHCE gene exon 5 is replaced with an RHD equivalent. Recent work has concluded that the terms weak and pmtial D phenotypes should be reploced by the term”ABERRANTD”,as all weak D phenotypes investigated illustrate a unique D Blood 2023 95:26992708. Vox Sang 2023。78 (suppl):079082 McAbantiD in diagnostic labs to measure FMH by flow cytometrymore accurate than the Rleihauer Testassay. ELLSAbiotinylated monoclonal IgG antiD in a petitive AEuropean pharmacopoeia studyparing this with traditional autoanalyzer method for antiD quantitation. Use of monoclonal antiD for prophylaxis. not only on the specificity and avidity of the monoclonal antibodyvia its Fv
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