【正文】
2. pulmonary hemorrhage 3. mortality Literature Search Pubmed: Clinical queries: patent ductus arteriosus Preview: prophylaxis AND pulmonary hemorrhage limit: language – English Age – newborn (birth1 month) Result of literature searching Cochrane systemic review articles – 1. Prophylactic intravenous indomethacin for preventing mortality and mordity in preterm infant (19 trials) (n=2872) Cochrane Database Rev. 2022。(1):CD004213 Result of literature searching Prevention and 18 month Outes of Serious Pulmonary Hemorrhage in Extremely Low Birth Weight Infants: results from the trial of indomethacin prophylaxis in preterms (TIPP) Pediatrics 2022。 RR: [,] RD: [,] NNT 4 ● Reduction of Gr 3 or 4 IVH [,] ● No significant reduction of PH RR= [,], RD [, ] ● No difference in mortality, RR= [ to ] ● Increase incidence of oliguria [,] Ibuprofen prophylaxis ● Significant reduced incidence of PDA [,], [,], NNT 3 ● Only 1 trial report incidence of P